Evidence map›Paper›PMID 30026692›Full record

ArticleFrontiers in aging neuroscience2018

The Moderating Role of COMT and BDNF Polymorphisms on Transfer Effects Following Multi- and Single-Domain Cognitive Training Among Community-Dwelling Shanghainese Older Adults.

Jiangling Jiang, Alexandra J Fiocco, Xinyi Cao, Lijuan Jiang, Wei Feng, Yuan Shen, Ting Li, Chunbo Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Jiangling JiangShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center (SMHC), Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Alexandra J FioccoDepartment of Psychology, Institute for Stress and Wellbeing Research, Ryerson University, Toronto, ON, Canada.
Xinyi CaoShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center (SMHC), Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lijuan JiangShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center (SMHC), Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wei FengDepartment of Psychiatry, Tongji Hospital of Tongji University, Shanghai, China.
Yuan ShenDepartment of Psychiatry, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
Ting LiShanghai Changning Mental Health Center, Shanghai, China.
Chunbo LiShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center (SMHC), Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Mental Health Center · CNTongji University · CNChinese Academy of Sciences · CNShanghai Changning Mental Health Center · CNToronto Metropolitan University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Given the increase in research suggesting benefit following cognitive training in older adults, researchers have started to investigate the potential moderating role of genetic polymorphisms on transfer effects. The objective of this study was to evaluate the moderating effect of catechol-O-methyltransferase (COMT) and brain-derived neurotrophic factor (BDNF) polymorphisms on transfer effects following a single-domain or multi-domain training intervention in healthy community-dwelling older adults. A total of 104 men and women living in Shanghai were randomized to a multi-domain or a single-domain cognitive training (SDCT) group. COMT rs4818 SNP and the BDNF rs6265 SNP were analyzed from blood. At pre-intervention, post-intervention and at 6-month follow-up, participants completed the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), the Color-Word Stroop Test (CWST), the Trails Making Test (TMT) and the Visual Reasoning Test (VRT). COMT was found to moderate immediate memory transfer effects following single-domain training only, with G/- carriers displaying greater benefits than C/C carriers. BDNF was found to moderate attention and inhibition independent of the training, with Met/- carriers displaying better performance than Val/Val carriers. Overall, individualizing training methods with full consideration of genetic polymorphisms may promote the maximization of cognitive training benefits.

Indexed as

brain-derived neurotrophic factorcatechol-O-methyltransferasecognitive trainingsingle nucleotide polymorphismsuccessful aging

Identifiers

PMID30026692
PMCPMC6041383
OpenAlexW2808549994

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.