ArticleInternational journal of obesity (2005)2019
Causal relationships between adiposity and childhood asthma: bi-directional Mendelian Randomization analysis.
Article in International journal of obesity (2005), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Visceral adiposity and respiratory outcomes in children and adults: a systematic review.International journal of obesity (2005) · 2022Pooled it
- Aspartame and asthma: immunomodulatory effects on airway inflammation.Respiratory research · 2026Article
- Causal risk factors for asthma in Mendelian randomization studies: A systematic review and meta-analysis.Clinical and translational allergy · 2022Review
- Obesity-related biomarkers underlie a shared genetic architecture between childhood body mass index and childhood asthma.Communications biology · 2022Article
- Maternal body composition and gestational weight gain in relation to asthma control during pregnancy.PloS one · 2022Article
- The bidirectional association between wheezing and obesity during adolescence and the beginning of adulthood in the 1993 birth cohort, Pelotas, Brazil.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2022Article
- Gestational and Postpartum Weight Trajectories Among Women With and Without Asthma.American journal of epidemiology · 2021Article
- Separating the genetics of childhood and adult obesity: a validation study of genetic scores for body mass index in adolescence and adulthood in the HUNT Study.Human molecular genetics · 2021Article
- The Effects of Asthma on the Association Between Pulmonary Function and Obesity: A 16-Year Longitudinal Study.Journal of asthma and allergy · 2021Article
- Genetics of early growth traits.Human molecular genetics · 2020Review
- Body mass index growth trajectories, early pubertal maturation, and short stature.Pediatric research · 2020Article
- Association between Physician-Diagnosed Asthma and Weight Status among Chinese Children: The Roles of Lifestyle Factors.International journal of environmental research and public health · 2020Article
- Moving Beyond the Confines of Body Mass Index in the Quest to Understand Obese Asthma.American journal of respiratory and critical care medicine · 2020Article
- Association of pediatric obesity and asthma, pulmonary physiology, metabolic dysregulation, and atopy; and the role of weight management.Expert review of endocrinology & metabolism · 2019Review
- Elucidation of causal direction between asthma and obesity: a bi-directional Mendelian randomization study.International journal of epidemiology · 2019Article
- Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.American journal of human genetics · 2019Article
- Genetics and Gene-Environment Interactions in Childhood and Adult Onset Asthma.Frontiers in pediatrics · 2019Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesObesity and asthma are common chronic diseases and have been reported to be mutually causative. We investigated the causal direction of the relationship between adiposity and asthma using genetic markers as instrumental variables (IVs) in bi-directional Mendelian randomization (MR) analysis. SUBJECTS/
methodsWe used data from the Taiwan Children Health Study with 24 body mass index (BMI)-single-nucleotide polymorphisms (SNPs, combined into a weighted allelic score) and 16 asthma-SNPs (combined into two weighted allelic scores, separately for asthma inflammatory and antioxidative genes) to yield genetic IVs for adiposity and asthma, respectively.
resultsThe weighted allele score for BMI was strongly associated with adiposity (p = 2 × 10
conclusionsHigh adiposity may lead to asthma, whereas the effects of asthma on adiposity accumulation are likely to be small.
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