Evidence map›Paper›PMID 30026567›Full record

Trial reportScientific reports2018

A Pilot Randomized Controlled Trial to Explore Cognitive and Emotional Effects of Probiotics in Fibromyalgia.

Pablo Roman, Angeles F Estévez, Alonso Miras, Nuria Sánchez-Labraca, Fernando Cañadas, Ana B Vivas, Diana Cardona

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07738926 (A Prospective, Randomised, Controlled Crossover Study on the Effectiveness of Bifidobacterium Adolescentis PRL2019 in the Treatment of Juvenile Fibromyalgia), which is not on this map. Cited by 63 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 15 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07738926 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Prospective, Randomised, Controlled Crossover Study on the Effectiveness of Bifidobacterium Adolescentis PRL2019 in the Treatment of Juvenile Fibromyalgia

TypeinterventionalSponsorIstituto Giannina GasliniRan2026 to 2026Enrolled30ConditionsFibromyalgia, Fibromyalgia SyndromeArmsBifidobacterium adolescentis PRL2019, Placebo
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 15 syntheses or guidelines pooled it, 109 citations in OpenAlex.

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  16. Trial
  17. The Effect of Multiprobiotics on Memory and Attention in Fibromyalgia: A Pilot Randomized Controlled Trial.International journal of environmental research and public health · 2021
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Pablo RomanDepartamento de Enfermería, Fisioterapia y Medicina, Universidad de Almería, Almería, Spain.
Angeles F EstévezCERNEP Research Center, Universidad de Almería, Almería, Spain. mafernan@ual.es.
Alonso MirasIndependent Researcher, Almería, Spain.
Nuria Sánchez-LabracaDepartamento de Enfermería, Fisioterapia y Medicina, Universidad de Almería, Almería, Spain.
Fernando CañadasCERNEP Research Center, Universidad de Almería, Almería, Spain.
Ana B VivasPsychology Department, The University of Sheffield International Faculty, City College, Sheffield, Greece.
Diana CardonaDepartamento de Enfermería, Fisioterapia y Medicina, Universidad de Almería, Almería, Spain.
University of Almería · ESUniversitat Jaume I · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has recently been found that microbes in the gut may regulate brain processes through the gut microbiota-brain axis, which modulates affection, motivation and higher cognitive functions. According to this finding, the use of probiotics may be a potential treatment to improve physical, psychological and cognitive status in clinical populations with altered microbiota balance such as those with fibromyalgia (FMS). Thus, the aim of the present pilot study with a double-blind, placebo-controlled, randomised design was to test whether a multispecies probiotic may improve cognition, emotional symptoms and functional state in a sample of patients diagnosed with FMS. Pain, impact of FMS, quality of life, anxiety and depressive symptoms were measured during the pre- and post-intervention phases; participants also completed two computerised cognitive tasks to assess impulsive choice and decision-making. Finally, urinary cortisol concentration was determined. To our knowledge, this is the first study that explore the effect of a multispecies probiotic in FMS patients. Our results indicated that probiotics improved impulsivity and decision-making in these patients. However, more research is needed to further explore the potential effects of probiotics on other cognitive functions affected in FMS as well as in other clinical populations.

Indexed as

CognitionDecision MakingDouble-Blind MethodEmotionsFemaleFibromyalgiaGastrointestinal MicrobiomeHumansImpulsive BehaviorMaleMiddle AgedPilot ProjectsProbioticsQuality of Life

Identifiers

PMID30026567
PMCPMC6053373
OpenAlexW2884412003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.