ArticleScientific reports2018
Runx1-Stat3 signaling regulates the epithelial stem cells in continuously growing incisors.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- JAK-STAT signaling: molecular mechanism and targeted treatment in dento-maxillofacial abnormalities.International journal of oral science · 2026Review
- Decoding dental mesenchymal stem cells diversity: single-cell transcriptomics maps heterogeneity in molar development.Frontiers in cell and developmental biology · 2025Review
- Slc26a2-mediated sulfate metabolism is important in tooth development.Disease models & mechanisms · 2024Article
- Single-cell map of dynamic cellular microenvironment of radiation-induced intestinal injury.Communications biology · 2023Article
- RUNX1-Regulated Signaling Pathways in Ovarian Cancer.Biomedicines · 2023Review
- Loss of Stat3 in OsterixCell & bioscience · 2023Article
- On-demand chlorine dioxide solution enhances odontoblast differentiation through desulfation of cell surface heparan sulfate proteoglycan and subsequent activation of canonical Wnt signaling.Frontiers in cell and developmental biology · 2023Article
- Ras signaling and RREB1 are required for the dissociation of medial edge epithelial cells in murine palatogenesis.Disease models & mechanisms · 2022Article
- The Association Between Runx Signaling and Craniofacial Development and Disease.Current osteoporosis reports · 2022Review
- Article
- New insight into dental epithelial stem cells: Identification, regulation, and function in tooth homeostasis and repair.World journal of stem cells · 2020Review
- Article
- STAT3-PTTG11 abrogation inhibits proliferation and induces apoptosis in malignant glioma cells.Oncology letters · 2020Article
- Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration.Development (Cambridge, England) · 2020Article
- Observation of the Epithelial Cell Behavior in the Nasal Septum During Primary Palate Closure in Mice.Frontiers in physiology · 2020Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Rodent incisors grow permanently and the homeostasis of enamel production is maintained by a continuous supply of epithelial progenitors from putative stem cells in the cervical loop. We herein report that Runx1 regulates the Lgr5-expressing epithelial stem cells and their subsequent continuous differentiation into ameloblasts. Mice deficient in epithelial Runx1 demonstrate remarkable shortening of the incisors with underdevelopment of the cervical loop and enamel defects. In this mutant cervical loop, the proliferation of the dental epithelium was significantly disturbed and the expression of Lgr5 and enamel matrix proteins was remarkably downregulated. Interestingly, the expression of Socs3, an inhibitor of Stat3 signaling, was upregulated and Stat3 phosphorylation was suppressed specifically in the mutant cervical loop. The expression of Lgr5 and the enamel matrix protein in the wild-type incisor germs is disturbed by pharmaceutical Stat3 inhibition in vitro., of. Conversely, pharmaceutical activation of Stat3 rescues the defective phenotypes of the Runx1 mutant with upregulated Lgr5 and enamel matrix protein genes. The present results provide the first evidence of the role of Runx1 regulates the Lgr5-expressing epithelial stem cells and differentiation of ameloblast progenitors in the developing incisors. Our study also demonstrates that Stat3 modulates the Runx1-Lgr5 axis in the cervical loop.
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