Evidence map›Paper›PMID 30026549›Full record

ArticleScientific reports2018

Arylsulphatase A Pseudodeficiency (ARSA-PD), hypertension and chronic renal disease in Aboriginal Australians.

Dave Tang, Michaela Fakiola, Genevieve Syn, Denise Anderson, Heather J Cordell, Elizabeth S H Scaman, Elizabeth Davis, Simon J Miles, Toby McLeay, Sarra E Jamieson and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Functional Profiling ofCirculation. Genomic and precision medicine · 2025
    Article
  2. The role of sphingolipids in heart failure.European heart journal open · 2025
    Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Dave TangTelethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, 6008, Australia.
Michaela FakiolaNational Institute of Molecular Genetics, Milan, Italy.
Genevieve SynTelethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, 6008, Australia.
Denise AndersonTelethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, 6008, Australia.ORCID 0000-0003-0643-4136
Heather J CordellInstitute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, United Kingdom.
Elizabeth S H ScamanTelethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, 6008, Australia.
Elizabeth DavisTelethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, 6008, Australia.
Simon J MilesNgangganawili Aboriginal Health Service, Wiluna, Western Australia, 6646, Australia.
Toby McLeayNgangganawili Aboriginal Health Service, Wiluna, Western Australia, 6646, Australia.
Sarra E JamiesonTelethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, 6008, Australia.
Timo LassmannTelethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, 6008, Australia.
Jenefer M BlackwellTelethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, 6008, Australia. jenefer.blackwell@telethonkids.org.au.
The Kids Research Institute Australia · AUIstituto Nazionale Genetica Molecolare · ITNewcastle University · GB

Funding

Department of Health | National Health and Medical Research Council (NHMRC) APP634301
6 · The paper itself

Abstract

Chronic renal disease (CRD) associated with cardiovascular disease (CVD) and/or type 2 diabetes (T2D) is a significant problem in Aboriginal Australians. Whole exome sequencing data (N = 72) showed enrichment for ClinVar pathogenic variants in gene sets/pathways linking lipoprotein, lipid and glucose metabolism. The top Ingenuity Pathway Analysis canonical pathways were Farsenoid X Receptor and Retinoid Receptor (FXR/RXR; (P = 1.86 × 10

Indexed as

AustraliaCase-Control StudiesCerebroside-SulfataseExome SequencingFemaleGene Regulatory NetworksGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansHypertensionMaleOdds RatioPolymorphism, Single NucleotideRenal Insufficiency, ChronicCerebroside-Sulfatase

Identifiers

PMID30026549
PMCPMC6053446
OpenAlexW2883859112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.