Evidence map›Paper›PMID 30026504›Full record

Trial reportJournal of human genetics2018

Association of coding and UTR variants in the known regions with wet age-related macular degeneration in Han Chinese population.

Lulin Huang, Xiongze Zhang, Pancy O S Tam, Haoyu Chen, Fang Hao, Chi-Pui Pang, Fen Wen, Zhenglin Yang

Abstract readClinical TrialMulticenter Study
PubMed Publisher
In one paragraph

Trial report in Journal of human genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Lulin HuangSichuan Provincial Key Laboratory for Human Disease Gene Study and the Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Xiongze ZhangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Pancy O S TamDepartment of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China.
Haoyu ChenJoint Shantou International Eye Center, Shantou University and Chinese University of Hong Kong, Shantou, China.ORCID http://orcid.org/0000-0003-0676-4610
Fang HaoSichuan Provincial Key Laboratory for Human Disease Gene Study and the Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Chi-Pui PangDepartment of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China.
Fen WenState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. wenfeng208@foxmail.com.
Zhenglin YangSichuan Provincial Key Laboratory for Human Disease Gene Study and the Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China. zliny@yahoo.com.
Chinese University of Hong Kong · HKUniversity of Electronic Science and Technology of China · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is the leading cause worldwide of severe visual impairment among people older than 55 years of age. This study aimed to investigate the genetic association between coding and untranslated region (UTR) variants in previously reported loci and exudative age-related macular degeneration (wet AMD) in a Han Chinese population. Using our previously published whole exome sequencing dataset of 349 wet AMD patients and 1253 controls, we searched for associations between coding and UTR variants of the 72 genes located within the 47 reported wet AMD loci regions. From these, 25 variants in 18 of the 72 genes with P < 10 × 10

Indexed as

Databases, Nucleic AcidPolymorphism, Single NucleotideUntranslated RegionsAsian PeopleChinaCohort StudiesFemaleHumansMacular DegenerationMaleUntranslated Regions

Identifiers

PMID30026504
OpenAlexW2884835545

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.