Evidence map›Paper›PMID 30026331›Full record

ArticleCancer research2018

Oncogenic BRAF

Tamer B Shabaneh, Aleksey K Molodtsov, Shannon M Steinberg, Peisheng Zhang, Gretel M Torres, Gadisti A Mohamed, Andrea Boni, Tyler J Curiel, Christina V Angeles, Mary Jo Turk

Abstract read
In one paragraph

Article in Cancer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 96 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Integrated approaches to sensitizing melanoma to radiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Review
  7. Review
  8. The immunology of vitiligo.Nature reviews. Immunology · 2026
    Review
  9. Article
  10. Review
  11. Review
  12. BRAF mutation and tumor immune microenvironment in new era.American journal of cancer research · 2026
    Review
  13. Article
  14. Article
  15. Article
  16. Regulatory T cells inhibit CD8bioRxiv : the preprint server for biology · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Implication of Immunobiological Function of Melanocytes in Dermatology.Clinical reviews in allergy & immunology · 2025
    Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Tamer B ShabanehDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Aleksey K MolodtsovDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Shannon M SteinbergDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Peisheng ZhangDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Gretel M TorresDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Gadisti A MohamedDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.ORCID 0000-0002-4880-5110
Andrea BoniSpectrum Healthcare Partners, South Portland, Maine.
Tyler J CurielDivision of Hematology & Medical Oncology, and Cancer Therapy & Research Center, University of Texas Health Science Center, San Antonio, Texas.
Christina V AngelesDepartment of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
Mary Jo TurkDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire. Mary.jo.turk@dartmouth.edu.
Dartmouth College · USDartmouth–Hitchcock Medical Center · USMass General Brigham · USThe University of Texas Health Science Center at San Antonio · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
IMMUNOBIOLOGY OF MYELOID AND LYMPHOID CELLST32AI007363 · NIAID · DARTMOUTH COLLEGE · PI Claudia V Jakubzick · 1990 to 2026
$9.5M
Tissue Resident memory T cell responses to cancerR01CA225028 · NCI · DARTMOUTH COLLEGE · PI Mary Jo Turk · 2018 to 2026
$4.9M
Center for Molecular, Cellular, and Translational ImmunologyP30GM103415 · NIGMS · DARTMOUTH COLLEGE · PI GREEN, WILLIAM R · 2012 to 2015
$4.7M
(PQ#3) Novel tumor intrinsic PD-L1 signals direct tumor immune cell infiltrationR01CA205965 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI REEVES, WILLIAM BRIAN · 2017 to 2021
$3.2M
Targeting VISTA eradicates large, established PD-1/CTLA-4 resistant tumorsR01CA214062 · NCI · DARTMOUTH COLLEGE · PI NOELLE, RANDOLPH J., TURK, MARY JO · 2017 to 2021
$2.8M
Mechanisms of concomitant tumor immunity and autoimmunityR01CA120777 · NCI · DARTMOUTH COLLEGE · PI TURK, MARY JO · 2006 to 2016
$2.5M
Immunological manipulation of resistance to molecularly targeted inhibitorsR21CA209375 · NCI · DARTMOUTH COLLEGE · PI TURK, MARY JO · 2016 to 2017
$388k
NCI NIH HHS P30 CA023108NCI NIH HHS R01 CA120777NCI NIH HHS R01 CA205965NCI NIH HHS R01 CA214062NCI NIH HHS R01 CA225028NCI NIH HHS R21 CA209375NIAID NIH HHS T32 AI007363NIGMS NIH HHS P30 GM103415
6 · The paper itself

Abstract

Regulatory T cells (Treg) are critical mediators of immunosuppression in established tumors, although little is known about their role in restraining immunosurveillance during tumorigenesis. Here, we employ an inducible autochthonous model of melanoma to investigate the earliest Treg and CD8 effector T-cell responses during oncogene-driven tumorigenesis. Induction of oncogenic BRAF

Indexed as

AnimalsAntigens, NeoplasmCarcinogenesisCD8-Positive T-LymphocytesCell Line, TumorDisease Models, AnimalGene Expression Regulation, NeoplasticHumansLymph NodesMelanocytesMelanomaMiceMutationProto-Oncogene Proteins B-rafPTEN PhosphohydrolaseReceptors, CCR4Antigens, NeoplasmBraf protein, mouseCcr4 protein, mouseProto-Oncogene Proteins B-rafPTEN PhosphohydrolasePTEN protein, humanReceptors, CCR4

Identifiers

PMID30026331
PMCPMC6319620
OpenAlexW2884395150

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.