ArticleThorax2019
Impact of cystic fibrosis on birthweight: a population based study of children in Denmark and Wales.
Article in Thorax, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- A Phase 3 Open-Label Study of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 through 11 Years of Age with Cystic Fibrosis and at Least OneAmerican journal of respiratory and critical care medicine · 2021Trial
- Systematic mapping of rare genetic disease studies using UK primary care electronic health records.European journal of human genetics : EJHG · 2026Review
- Maternal and fetal outcomes associated with CFTR modulator use during pregnancy: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2026Article
- Considerations for early life genetic therapies in cystic fibrosis.American journal of physiology. Lung cellular and molecular physiology · 2026Review
- A retrospective cohort study evaluating the growth and clinical outcomes of preterm and term infants with cystic fibrosis during the first 11 years of life.JPGN reports · 2026Article
- Evolution and Prognostic Variables of Cystic Fibrosis in Children and Young Adults: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Assessing the Predictive Capabilities of Autoregressive Integrated Moving Average and Linear Regression Models for Acute Changes in Clinical and Selected Laboratory Parameters in Children After Cardiac Surgery in the ICU.Children (Basel, Switzerland) · 2024Article
- Diagnosis and Management of Simple and Complicated Meconium Ileus in Cystic Fibrosis, a Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- Structural causal model with expert augmented knowledge to estimate the effect of oxygen therapy on mortality in the ICU.Artificial intelligence in medicine · 2023Article
- Gestational and pregestational diabetes in pregnant women with cystic fibrosis.Journal of clinical & translational endocrinology · 2022Article
- Educational achievements of children aged 10-11 years with cystic fibrosis. A data linkage study in Wales.International journal of population data science · 2022Article
- Healthcare resource utilization and costs among children with cystic fibrosis in the United States.Pediatric pulmonology · 2021Observational
- Long-Term Impact of Ivacaftor on Healthcare Resource Utilization Among People with Cystic Fibrosis in the United States.Pulmonary therapy · 2021Article
- Choline in cystic fibrosis: relations to pancreas insufficiency, enterohepatic cycle, PEMT and intestinal microbiota.European journal of nutrition · 2021Review
- Identifying children with Cystic Fibrosis in population-scale routinely collected data in Wales: A Retrospective Review.International journal of population data science · 2020Article
- Impact of newborn screening on outcomes and social inequalities in cystic fibrosis: a UK CF registry-based study.Thorax · 2020Article
- Initial regional evaluation of the Cystic Fibrosis Newborn Screening Program: data from the Mediterranean coast of TurkeyTurkish journal of medical sciences · 2019Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundPoor growth during infancy and childhood is a characteristic feature of cystic fibrosis (CF). However, the impact of CF on intrauterine growth is unclear. We studied the effect of CF on birth weight in Denmark and Wales, and assessed whether any associations are due to differences in gestational age at birth.
methodsWe conducted national registry linkage studies in two countries, using data for 2.2 million singletons born in Denmark (between 1980 and 2010) and Wales (between 1998 and 2015). We used hospital inpatient and outpatient data to identify 852 children with CF. Using causal mediation methods, we estimated the direct and indirect (via gestational age) effect of CF on birth weight after adjustment for sex, parity and socioeconomic background. We tested the robustness of our results by adjusting for additional factors such as maternal smoking during pregnancy in subpopulations where these data were available.
resultsBabies with CF were more likely to be born preterm and with low birth weight than babies with no CF (12.7% vs 5% and 9.4% vs 5.8% preterm; 11.9% vs 4.2% and 11% vs 5.4% low birth weight in Denmark and Wales, respectively). Using causal mediation methods, the total effect of CF on birth weight was estimated to be -178.8 g (95% CI -225.43 to -134.47 g) in the Danish population and -210.08 g (95% CI -281.97 to -141.5 g) in the Welsh population. About 40% of this effect of CF on birth weight was mediated through gestational age.
conclusionsCF significantly impacts on intrauterine growth and leads to lower birth weight in babies with CF, which is only partially explained by shorter gestation.
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Registered trials
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