Evidence map›Paper›PMID 30026293›Full record

ArticleGenes & development2018

Mutations in microRNA processing genes in Wilms tumors derepress the

Kenneth S Chen, Emily K Stroup, Albert Budhipramono, Dinesh Rakheja, Diana Nichols-Vinueza, Lin Xu, Sarai H Stuart, Abhay A Shukla, Claudette Fraire, Joshua T Mendell and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Article
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  5. Article
  6. Article
  7. Pediatric fibromyxoid brachial plexus tumor with YWHAZ::PLAG1 gene fusion: a case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Article
  8. Review
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  16. Review
  17. [MicroRNA-200c-3p inhibits proliferation of nephroblastoma cells by targeting CCNE2].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020
    Article
  18. Article
  19. Article
  20. The association ofJournal of Cancer · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Kenneth S ChenDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Emily K StroupDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Albert BudhipramonoDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Dinesh RakhejaDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.ORCID 0000-0001-6888-7902
Diana Nichols-VinuezaDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Lin XuDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Sarai H StuartDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Abhay A ShuklaDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Claudette FraireDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Joshua T MendellDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
James F AmatrudaDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.ORCID 0000-0002-9901-2137
The University of Texas Southwestern Medical Center · USCenter for Cancer and Blood Disorders · USHoward Hughes Medical Institute · US

Funding

University of Texas Southwestern Medical Center SPORE in Kidney CancerP50CA196516 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI XIANKAI SUN · 2016 to 2026
$24.7M
The intersection of RNA biology and tumor biologyR35CA197311 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MENDELL, JOSHUA T · 2015 to 2021
$5.1M
ANTECEDANTS SEQUELAE OF CHILDHOOD ONSET DISEASEK12HD068369 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI SKAPEK, STEPHEN X · 2011 to 2020
$3.0M
The role of PLAG1 in Wilms tumor formationK08CA207849 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI CHEN, KENNETH SUNG-MAN · 2017 to 2021
$781k
Howard Hughes Medical InstituteNCI NIH HHS K08 CA207849NCI NIH HHS P50 CA196516NCI NIH HHS R35 CA197311NICHD NIH HHS K12 HD068369
6 · The paper itself

Abstract

Many childhood Wilms tumors are driven by mutations in the microRNA biogenesis machinery, but the mechanism by which these mutations drive tumorigenesis is unknown. Here we show that the transcription factor

Indexed as

MutationAnimalsCell Line, TumorDNA-Binding ProteinsDNA Copy Number VariationsGene Expression Regulation, NeoplasticHumansInsulin-Like Growth Factor IIKidneyMiceMicroRNAsRNA Processing, Post-TranscriptionalTOR Serine-Threonine KinasesTranscription FactorsWilms TumorDNA-Binding ProteinsIGF2 protein, humanInsulin-Like Growth Factor IIMicroRNAsMIRN16 microRNA, humanMIRN34 microRNA, humanPLAG1 protein, humanTOR Serine-Threonine KinasesTranscription FactorsIGF2kidneymicroRNA processingpediatric cancerPLAG1Wilms tumor

Identifiers

PMID30026293
PMCPMC6075147
OpenAlexW2884448655

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.