ArticleThe Journal of cell biology2018
Draxin acts as a molecular rheostat of canonical Wnt signaling to control cranial neural crest EMT.
Article in The Journal of cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Who cites it
35 citing papers in PubMed, 59 citations in OpenAlex.
- Neural crest gene regulatory networks as drivers of development, diversification and disease.Nature reviews. Molecular cell biology · 2026Review
- Cellular diversity of the developing chick trigeminal ganglion at single-cell resolution.bioRxiv : the preprint server for biology · 2026Article
- KLF7 orchestrates hippocampal development through neurogenesis and Draxin-mediated neuronal migration.Development (Cambridge, England) · 2025Article
- CRISPR-Cas13d as a molecular tool to achieve targeted gene expression knockdown in chick embryos.Developmental biology · 2025Article
- Tlx3 mediates neuronal differentiation and proper condensation of the developing trigeminal ganglion.Developmental biology · 2024Article
- CRISPR-Cas13d as a molecular tool to achieve targeted gene expression knockdown in chick embryos.bioRxiv : the preprint server for biology · 2024Article
- Post-transcriptional regulation as a conserved driver of neural crest and cancer-cell migration.Current opinion in cell biology · 2024Review
- "Beyond transcription: How post-transcriptional mechanisms drive neural crest EMT".Genesis (New York, N.Y. : 2000) · 2024Review
- Maintenance of pluripotency-like signature in the entire ectoderm leads to neural crest stem cell potential.Nature communications · 2023Article
- Downregulation of PMP22 ameliorates myelin defects in iPSC-derived human organoid cultures of CMT1A.Brain : a journal of neurology · 2023Article
- The Tumor SuppressorJournal of developmental biology · 2023Article
- Propofol-Induced miR-493-3p Inhibits Growth and Invasion of Gastric Cancer through Suppression of DKK1-Mediated Wnt/Disease markers · 2023Article
- Temporal changes in plasma membrane lipid content induce endocytosis to regulate developmental epithelial-to-mesenchymal transition.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification.eLife · 2022Article
- Time to go: neural crest cell epithelial-to-mesenchymal transition.Development (Cambridge, England) · 2022Review
- MicroRNAs in neural crest development and neurocristopathies.Biochemical Society transactions · 2022Review
- Expression atlas of avian neural crest proteins: Neurulation to migration.Developmental biology · 2022Article
- Modeling cartilage pathology in mucopolysaccharidosis VI using iPSCs reveals early dysregulation of chondrogenic and metabolic gene expression.Frontiers in bioengineering and biotechnology · 2022Article
- DRAXIN regulates interhemispheric fissure remodelling to influence the extent of corpus callosum formation.eLife · 2021Article
- From Neural Crest to Definitive Roof Plate: The Dynamic Behavior of the Dorsal Neural Tube.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Neural crest cells undergo a spatiotemporally regulated epithelial-to-mesenchymal transition (EMT) that proceeds head to tailward to exit from the neural tube. In this study, we show that the secreted molecule Draxin is expressed in a transient rostrocaudal wave that mirrors this emigration pattern, initiating after neural crest specification and being down-regulated just before delamination. Functional experiments reveal that Draxin regulates the timing of cranial neural crest EMT by transiently inhibiting canonical Wnt signaling. Ectopic maintenance of Draxin in the cranial neural tube blocks full EMT; while cells delaminate, they fail to become mesenchymal and migratory. Loss of Draxin results in premature delamination but also in failure to mesenchymalize. These results suggest that a pulse of intermediate Wnt signaling triggers EMT and is necessary for its completion. Taken together, these data show that transient secreted Draxin mediates proper levels of canonical Wnt signaling required to regulate the precise timing of initiation and completion of cranial neural crest EMT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.