Evidence map›Paper›PMID 30026196›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Electrostatic lock in the transport cycle of the multidrug resistance transporter EmrE.

Josh V Vermaas, Susan B Rempe, Emad Tajkhorshid

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Article
  3. Protonated Structure of EmrE Reveals C-terminal Tail Gating Mechanism.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Backbone and sidechainBiomolecular NMR assignments · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Identifying and quantifying membrane interactions of the protein human cis-prenyltransferase.Protein science : a publication of the Protein Society · 2025
    Article
  11. Review
  12. Peripheral positions encode transport specificity in the small multidrug resistance exporters.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Asymmetric protonation of glutamate residues drives a preferred transport pathway in EmrE.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Josh V VermaasCenter for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.ORCID 0000-0003-3139-6469
Susan B RempeBiological and Engineering Sciences Center, Sandia National Laboratories, Albuquerque, NM 87185 emad@life.illinois.edu slrempe@sandia.gov.
Emad TajkhorshidCenter for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801; emad@life.illinois.edu slrempe@sandia.gov.ORCID 0000-0001-8434-1010
University of Illinois Urbana-Champaign · USSandia National Laboratories · US

Funding

Synthetic Antigen Binder CoreU54GM087519 · NIGMS · UNIVERSITY OF CHICAGO · PI NAKAMOTO, ROBERT K. · 2010 to 2017
$31.9M
WHOLE CELL SIMULATIONP41GM104601 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI TAJKHORSHID, EMAD · 2012 to 2021
$19.0M
NIGMS NIH HHS P41 GM104601NIGMS NIH HHS U54 GM087519
6 · The paper itself

Abstract

EmrE is a small, homodimeric membrane transporter that exploits the established electrochemical proton gradient across the

Indexed as

Drug Resistance, Multiple, BacterialAntiportersBiological TransportCryoelectron MicroscopyEscherichia coliEscherichia coli ProteinsGlutamic AcidHydrogen BondingLipid BilayersMolecular Dynamics SimulationProtein BindingProtein ConformationProtonsStatic ElectricityAntiportersEmrE protein, E coliEscherichia coli ProteinsGlutamic AcidLipid BilayersProtonsmembrane proteinmolecular dynamicsproton-coupled transportstructure refinement

Identifiers

PMID30026196
PMCPMC6094130
OpenAlexW2885020080

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.