Evidence map›Paper›PMID 30025944›Full record

ArticleThe journal of pain2018

Sex and Race Differences in Pain Sensitization among Patients with Chronic Low Back Pain.

Samantha M Meints, Victor Wang, Robert R Edwards

Registry-linked trialAbstract read
In one paragraph

Article in The journal of pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03644810 (The Efficiency of Conditioned Pain Modulation is Associated With Levels of Pain Catastrophizing in Patients With Chronic Low Back Pain), which is not on this map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03644810 nacompletednot on this map

The Efficiency of Conditioned Pain Modulation is Associated With Levels of Pain Catastrophizing in Patients With Chronic Low Back Pain

TypeinterventionalSponsorAalborg UniversityRan2017 to 2018Enrolled44ConditionsCatastrophizing Pain, Pain, Somatic, Chronic Low Back PainArmsPPT measurement, Pain catastrophizing scale, Cold Pressor Test
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 90 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Samantha M MeintsDepartment of Anesthesiology, Pain Management Center, Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, Massachusetts.. Electronic address: smeints@bwh.harvard.edu.
Victor WangDepartment of Anesthesiology, Pain Management Center, Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, Massachusetts.
Robert R EdwardsDepartment of Anesthesiology, Pain Management Center, Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, Massachusetts.
Brigham and Women's Hospital · US

Funding

Training in Orthopaedic and Musculoskeletal Clinical ResearchT32AR055885 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KATZ, JEFFREY NEIL, LOSINA, ELENA · 2008 to 2023
$4.0M
Opioid-induced change in pain sensitivity and modulation: Links to opioid misuseR21DA041020 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI EDWARDS, ROBERT R · 2016 to 2017
$488k
NIAMS NIH HHS T32 AR055885NIDA NIH HHS R21 DA041020
6 · The paper itself

Abstract

Growing evidence suggests that chronic low back pain (CLBP) is associated with pain sensitization, and that there are sex and race disparities in CLBP. Given the sex and race differences in pain sensitization, this has been hypothesized as a mechanism contributing to the sex and race disparities in CLBP. This study examined sex and race differences in pain sensitization among patients with CLBP, as well as the role of catastrophizing as a potential mediator of those differences. The study found that compared with men, women required less pressure to produce deep muscle pain and rated mechanical punctate pain as more painful. Compared with non-Hispanic white patients, black patients demonstrated greater pain sensitivity for measures of deep muscle hyperalgesia and mechanical punctate pain. Furthermore, catastrophizing partially mediated the race differences in deep muscle pain such that black participants endorsed greater pain catastrophizing, which partially accounted for their increased sensitivity to, and temporal summation of, deep muscle pain. Taken together, these results support the need to further examine the role of catastrophizing and pain sensitization in the context of sex and race disparities in the experience of CLBP. PERSPECTIVE: This study identifies sex and race differences in pain sensitization among patients with CLBP. Further, it recognizes the role of catastrophizing as a contributor to such race differences. More research is needed to further dissect these complex relationships.

Indexed as

AdultBlack or African AmericanCatastrophizationChronic PainFemaleHumansLow Back PainMaleMiddle AgedPain PerceptionPain ThresholdSex FactorsWhite PeopleChronic low back painpain sensitizationquantitative sensory testingracesex

Identifiers

PMID30025944
PMCPMC6289602
OpenAlexW2883726661

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.