Evidence map›Paper›PMID 30025864›Full record

ArticleCellular immunology2018

IL-10 induces an immune repressor pathway in sepsis by promoting S100A9 nuclear localization and MDSC development.

Isatou Bah, Ajinkya Kumbhare, Lam Nguyen, Charles E McCall, Mohamed El Gazzar

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Cellular immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 79 citations in OpenAlex.

  1. Trial
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  3. Myeloid-derived suppressor cells in sepsis: drivers of persistent immunosuppression and targets for precision immunotherapy.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  4. Disulfidptosis modification patterns are involved in the immune microenvironment regulation of septic acute respiratory distress syndrome.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Isatou BahDepartment of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN 37614, United States.
Ajinkya KumbhareDepartment of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN 37614, United States.
Lam NguyenDepartment of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN 37614, United States.
Charles E McCallDepartment of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, United States.
Mohamed El GazzarDepartment of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN 37614, United States. Electronic address: elgazzar@etsu.edu.
East Tennessee State University · USWake Forest University · US

Funding

MicroRNAs and myeloid cell development during sepsisR01GM103887 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI ELGAZZAR, MOHAMED A. · 2013 to 2018
$1.4M
NIGMS NIH HHS R01 GM103887
6 · The paper itself

Abstract

The myeloid-related protein S100A9 reprograms Gr1

Indexed as

AnimalsAntibodiesAntigens, LyCalgranulin BCD11b AntigenCell NucleusDisease Models, AnimalImmunosuppression TherapyInterleukin-10Interleukin-6MaleMiceMice, Inbred BALB CMice, KnockoutMyeloid CellsMyeloid-Derived Suppressor CellsAntibodiesAntigens, LyCalgranulin BCD11b AntigenIL10 protein, mouseInterleukin-10Interleukin-6S100A9 protein, mouseInflammationInnate immunityMDSCsS100A9Sepsis

Identifiers

PMID30025864
PMCPMC6129403
OpenAlexW2880632487

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.