Evidence map›Paper›PMID 30025518›Full record

ArticleNutrition journal2018

Erythrocyte DHA and AA in infancy is not associated with developmental status and cognitive functioning five years later in Nepalese children.

Sigrun Henjum, Ingrid Kvestad, Merina Shrestha, Manjeswori Ulak, Ram K Chandyo, Andrew L Thorne-Lyman, Prakash S Shrestha, Marian Kjellevold, Mari Hysing, Tor A Strand

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Article in Nutrition journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sigrun HenjumOsloMet - Oslo Metropolitan University, Postboks 4, St. Olavs plass, Oslo, Norway. sigrun.henjum@hioa.no.ORCID 0000-0002-0671-2688
Ingrid KvestadRegional Center for Child and Youth Mental Health and Child Welfare, West, Uni Research Health, Bergen, Norway.
Merina ShresthaDepartment of Child Health, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
Manjeswori UlakDepartment of Child Health, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
Ram K ChandyoDepartment of Community Medicine, Kathmandu Medical College, P.O. Box 21266, Kathmandu, Nepal.
Andrew L Thorne-LymanCenter for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Prakash S ShresthaDepartment of Child Health, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
Marian KjellevoldInstitute of Marine Research, 5817, Bergen, Norway.
Mari HysingRegional Center for Child and Youth Mental Health and Child Welfare, West, Uni Research Health, Bergen, Norway.
Tor A StrandDivision for Medical Services, Innlandet Hospital Trust, Lillehammer, Norway.

Funding

Norges Forskningsråd 172226South-Eastern Norway Regional Health Authority 2012090USAID Feed the Future Innovation Laboratory for Nutrition AID-OAA-L-1-00005
6 · The paper itself

Abstract

backgroundLong chain polyunsaturated fatty acids (LCPUFA) especially docosahexaenoic acid (DHA) and arachidonic acid (AA) are crucial for normal brain development in utero and in early infancy. Data on fatty acid status and cognitive development in infants and children from low-income countries are scarce.

methodsWe examined the association between the DHA and AA status in infancy (n = 320) and developmental status and cognitive functioning five years later. At five years of age, we measured development by the Ages and Stages Questionnaire 3rd. ed. (ASQ-3) and cognitive functioning by subtests from the neuropsychological test battery NEPSY II. In addition, infant fatty acid composition in red blood cells (RBC) was analyzed. In multiple linear and logistic regression models, we estimated the associations between DHA and AA status in infancy and scores on the ASQ-3 and the NEPSY II subtests.

resultsThere were no notable associations between infant AA and DHA status, and the scores on the ASQ-3 and the NEPSY II subtests five years later. It should be noted that we found better than expected concentrations of erythrocyte DHA and AA among the infants, and the ASQ scores were left-skewed, which limited the ability to identify associations.

conclusionDHA and AA status in infancy is seemingly not related to neurodevelopment measured 5 years later in this peri-urban population from Nepal.

Indexed as

Arachidonic AcidChild DevelopmentCluster AnalysisCognitionDocosahexaenoic AcidsErythrocytesFemaleFollow-Up StudiesHumansInfantMaleNepalNeuropsychological TestsArachidonic AcidDocosahexaenoic AcidsAACognitive functioningDevelopmental statusDHAFollow up studyNepalese childrenPlasma phospholipidsPolyunsaturated fatty acids

Identifiers

PMID30025518
PMCPMC6053716

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.