SynthesisNeuroepidemiology2018
Presentation, Evaluation, Management, and Outcomes of Acute Stroke in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis.
Synthesis in Neuroepidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Association of the COVID-19 pandemic on stroke admissions and treatment globally: a systematic review.BMJ open · 2023Pooled it
- Systematic Review of Existing Stroke Guidelines: Case for a Change.BioMed research international · 2022Pooled it
- A Systematic Review of Household and Family Alcohol Use and Childhood Neurodevelopmental Outcomes in Low- and Middle-Income Countries.Child psychiatry and human development · 2021Pooled it
- A Systematic Review of Household and Family Alcohol Use and Adolescent Behavioural Outcomes in Low- and Middle-Income Countries.Child psychiatry and human development · 2021Pooled it
- Ischemic stroke in Morocco: a systematic review.BMC neurology · 2019Pooled it
- Predictors of in-hospital case-fatality in patients with stroke at the National Hospital of the Kyrgyz Republic: a retrospective cohort study.BMC neurology · 2026Article
- Impact of Socioeconomic Status on Functional Outcome After Stroke in Ulaanbaatar, Mongolia.Journal of the American Heart Association · 2026Article
- Real-world analysis and future trends of stroke-related mortality and burden in Pudong: a comprehensive study from 2005 to 2035.BMJ open · 2025Article
- Challenges in the Management of Stroke in Intensive Care Units in Low- and Middle-Income Countries.Neurocritical care · 2025Review
- Mortality rate of stroke and its determinants in Africa: An umbrella review of systematic review and meta-analysis.Global epidemiology · 2025Review
- C-REGS2-A multinational, high-quality comparative effectiveness study of Cerebrolysin in moderate acute ischemic stroke.International journal of stroke : official journal of the International Stroke Society · 2025Article
- Development and validation of a clinical prediction model for concurrent pulmonary infection in convalescent patients with intracerebral hemorrhage.Biomedical engineering online · 2025Article
- Perioperative stroke.Nature reviews. Disease primers · 2024Review
- Identifying factors in the provision of intravenous stroke thrombolysis in Malaysia: a multiple case study from the healthcare providers' perspective.BMC health services research · 2024Article
- Ongoing Healthcare Disparities in neuroHIV: Addressing Gaps in the Care Continuum.Current HIV/AIDS reports · 2023Review
- Pragmatic solutions to reduce the global burden of stroke: a World Stroke Organization-Lancet Neurology Commission.The Lancet. Neurology · 2023Review
- Phenomic Studies on Diseases: Potential and Challenges.Phenomics (Cham, Switzerland) · 2023Review
- Big Data-Enabled Analysis of Factors Affecting Medical Expenditure in the Cerebral Infarction of a Developing City in Western China.Risk management and healthcare policy · 2023Article
- Stroke thrombolysis in a middle-income country: A case study exploring the determinants of its implementation.Frontiers in neurology · 2022Article
- Characteristics of stroke service implementation in Armenia.Frontiers in neurology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
aimsWe performed a systematic review to evaluate stroke presentation, evaluation, management, and outcomes among studies conducted in low- and middle-income countries (LMIC).
methodsWe searched MEDLINE (Ovid), Embase (Elsevier), and the Global Health (EBSCOhost) databases between January 2005 and June 2017 for studies conducted in LMICs defined by the World Bank. We pooled prevalence estimates using an inverse-variance weighting method and stratified by the country income group.
resultsThe search identified 36 hospital-based studies (64,256 participants) in LMICs. Mean (SD) age ranged from 51 (14) to 72 (12) years, and 29-56% of patients were women. Hypertension was the most commonly reported risk factor (64% [95% CI 59-69]). In settings where MRI was not used, head CT scans were reported among 90% patients (95% CI 79-97). Overall, 3% (95% CI 2-4) of patients were treated with tissue plasminogen activator, and 78% (95% CI 66-88) were treated with antiplatelet therapy. Overall, the rate of in-hospital mortality was 14% (95% CI 10-19), and the rate of in-hospital pneumonia was 17% (95% CI 14-20).
conclusionsOur review revealed the low use of evidence-based practices for acute stroke care in LMIC. The true use in hospitals that do not conduct this research is probably even lower. Strategies to evaluate and improve health system performance for acute stroke care, including implantation of stroke units and making thrombolysis more available and affordable are needed in LMIC. Registration in Prospero: CRD42017069325.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.