ArticleEarly human development2018
Autonomic nervous system depression at term in neurologically normal premature infants.
Article in Early human development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Heart rate variability after hospital discharge in perinatal risk populations: a systematic review and meta-analysis.Pediatric research · 2026Pooled it
- Heart Rate Variability Analysis to Evaluate Autonomic Nervous System Maturation in Neonates: An Expert Opinion.Frontiers in pediatrics · 2022Pooled it
- A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows.Frontiers in neuroscience · 2021Pooled it
- Randomized trial evaluating sensorimotor stimulation and functional feeding in high-risk newborns: study protocol.Pediatric research · 2026Trial
- Maternal singing sustains preterm hospitalized newborns' autonomic nervous system maturation: an RCT.Pediatric research · 2024Trial
- Postnatal evolution of electrocardiographic parameters in preterm infants: a prospective longitudinal cohort study.European journal of pediatrics · 2026Article
- Preterm birth and birth weight extremes are associated with periodontal disease and tooth loss in the ARIC study.Scientific reports · 2026Article
- Autonomic nervous system maturation in preterm neonates: Correlation with gestational and postmenstrual age (ProMote).PloS one · 2026Article
- Visual and motor skills development in preterm and full-term infants: A protocol for longitudinal data collection.MethodsX · 2025Article
- Article
- Central Autonomic Network and Heart Rate Variability in Premature Neonates.Developmental neuroscience · 2024Article
- Autonomic markers of extubation readiness in premature infants.Pediatric research · 2023Article
- Comparing Full and Pre-Term Neonates' Heart Rate Variability in Rest Condition and during Spontaneous Interactions with Their Parents at Home.Healthcare (Basel, Switzerland) · 2023Article
- The Influence of Parent Education on the Neurobehavior and Sucking Reflexes of Very Preterm Infants.Brain sciences · 2022Article
- Maternal Singing but Not Speech Enhances Vagal Activity in Preterm Infants during Hospitalization: Preliminary Results.Children (Basel, Switzerland) · 2022Article
- Development of the Ontogenetic Self-Regulation Clock.International journal of molecular sciences · 2022Review
- Autonomic measures identify stress, pain, and instability associated with retinopathy of prematurity ophthalmologic examinations.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Pulmonary Resilience: Moderating the Association between Oxygen Exposure and Pulmonary Outcomes in Extremely Preterm Newborns.Neonatology · 2022Review
- Autonomic development in preterm infants is associated with morbidity of prematurity.Pediatric research · 2022Article
- Neonatal heart rate variability: a contemporary scoping review of analysis methods and clinical applications.BMJ open · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPremature infants are vulnerable to destructive brain injury and disturbed neurological development. Prematurity may alter maturation of the central autonomic nervous system (ANS).
aimsTo compare ANS function (using heart rate variability; HRV) between preterm infants with normal neuroimaging at term equivalent age and low-risk term controls. Study design, subjects. We performed a case-control study of preterm infants born ≤28 weeks gestational age that had normal brain imaging and archived continuous EKG data at term equivalent age. We documented other factors thought to influence ANS maturation (e.g. infection, ventilation days, and postnatal steroids). Controls were low-risk term gestational age newborns from uncomplicated pregnancies/deliveries. We characterized HRV metrics using frequency-(Welch periodogram) and time-domain (detrended fluctuation) analyses. Sympathetic tone was characterized by α
conclusionsAutonomic maturation is impaired in a premature extrauterine environment. In the absence of destructive brain injury, our data suggest an important role for disturbed programming in this impaired autonomic development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.