ArticleInvestigative ophthalmology & visual science2018
A Novel Tree Shrew (Tupaia belangeri) Model of Glaucoma.
Article in Investigative ophthalmology & visual science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 39 citations in OpenAlex.
- Cellular responses to short-term intraocular pressure elevation in a porcine eye explant model.Experimental eye research · 2025Article
- Early Peripapillary Choroidal Thinning during Myopia Development: A Potential Biomarker for Progressive Myopia Identified in Tree Shrews.Investigative ophthalmology & visual science · 2025Article
- The role of neurotrophic factors in retinal ganglion cell resiliency.Frontiers in cellular neuroscience · 2025Review
- Unexpected Retinal Abnormalities in the Cone-Dominant Northern Tree Shrew.Advances in experimental medicine and biology · 2025Article
- Visible-Light Optical Coherence Tomography Fibergraphy of the Tree Shrew Retinal Ganglion Cell Axon Bundles.IEEE transactions on medical imaging · 2024Article
- Study of tree shrew biology and models: A booming and prosperous field for biomedical research.Zoological research · 2024Review
- Article
- Heterogenous thinning of peripapillary tissues occurs early during high myopia development in juvenile tree shrews.Experimental eye research · 2024Article
- Cellular Characterization and Interspecies Evolution of the Tree Shrew Retina across Postnatal Lifespan.Research (Washington, D.C.) · 2024Article
- Description of a Nonhuman Primate Model of Retinal Ischemia/Reperfusion Injury.Translational vision science & technology · 2023Article
- Longitudinal Changes of Bruch's Membrane Opening, Anterior Scleral Canal Opening, and Border Tissue in Experimental Juvenile High Myopia.Investigative ophthalmology & visual science · 2023Article
- Orientation pinwheels in primary visual cortex of a highly visual marsupial.Science advances · 2022Article
- Anterior Segment Anatomy and Conventional Outflow Physiology of the Tree Shrew (Tupaia belangeri).Investigative ophthalmology & visual science · 2022Article
- A Novel Tree Shrew Model of Chronic Experimental Autoimmune Uveitis and Its Disruptive Application.Frontiers in immunology · 2022Article
- Intrinsically photosensitive retinal ganglion cells in glaucoma.Frontiers in cellular neuroscience · 2022Review
- Characteristics of Angiotensin I-converting enzyme 2, type II transmembrane serine protease 2 and 4 in tree shrew indicate it as a potential animal model for SARS-CoV-2 infection.Bioengineered · 2021Article
- A Novel Tree Shrew Model of Diabetic Retinopathy.Frontiers in endocrinology · 2021Article
- A novel tree shrew model of pulmonary fibrosis.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- Retinal Ganglion Cell Degeneration in a Rat Magnetic Bead Model of Ocular Hypertensive Glaucoma.Translational vision science & technology · 2021Article
- Connective Tissue Remodeling in Myopia and its Potential Role in Increasing Risk of Glaucoma.Current opinion in biomedical engineering · 2020Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Purpose: Primates and rodents are used widely as animal models of glaucoma, but each has significant limitations. Researchers need additional animal models that closely resemble the relevant anatomy and pathologic features of the human disease to more quickly advance research. We validate a novel glaucoma animal model in tree shrews (Tupaia belangeri). Methods: Experimental glaucoma was induced in adult tree shrews (n = 8) by injecting 50 μL of a 25 mg/mL ferromagnetic bead solution into the anterior chamber. Beads were directed into the iridocorneal angle with a magnet to impede aqueous outflow. Animals were followed for 3 months with weekly IOP measurements and biweekly spectral domain optical coherence tomography (SD-OCT) images of the optic nerve head. Histopathology of the optic nerve and optic nerve axon counts were completed at the end of the study. Results: The 12-week average mean IOP was 22.7 ± 3.6 and 8.6 ± 2.9 mm Hg in the treated and control eyes, respectively. Longitudinal analysis showed significant retinal nerve fiber layer (RNFL) thinning throughout the study. Axon counts were significantly reduced (59.7%) in treated versus control eyes. SD-OCT imaging showed cupping and posterior displacement of the lamina cribrosa in glaucomatous eyes. RNFL thickness and optic nerve axon counts were reduced consistent with IOP elevation. Optic nerves demonstrated histopathology consistent with glaucomatous optic neuropathy. Conclusions: Tree shrews with experimental glaucoma show key pathologic characteristics of the human disease. The tree shrew model of glaucoma has the potential to help researchers accelerate our understanding of glaucoma pathophysiology.
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