ArticleInvestigative ophthalmology & visual science2018
Effects of Corneal Hydration on Brillouin Microscopy In Vivo.
Article in Investigative ophthalmology & visual science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 82 citations in OpenAlex.
- Dual Optical Elastography Techniques Reveal the Regulation of Corneal Stiffness by Collagen XIV.Journal of biophotonics · 2026Article
- Correlation Analysis of Bowman's Layer Microdistortions and Corneal Biomechanics Changes Evaluated by Brillouin Microscopy After KLEx.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Article
- Application of the Brillouin Optical Scanning System in the Regional Corneal Biomechanical Evaluation of Keratoconus and Its Correlation with Corvis ST Parameters.Bioengineering (Basel, Switzerland) · 2025Article
- Assessing UVA and Laser-Induced Crosslinking via Brillouin Microscopy.Journal of biophotonics · 2025Article
- Diurnal variations in corneal biomechanics in healthy young adults.BMC ophthalmology · 2025Article
- The Application of Terahertz Technology in Corneas and Corneal Diseases: A Systematic Review.Bioengineering (Basel, Switzerland) · 2025Review
- Investigation of corneal hydration and the impact of cross-linking therapy on water retention using Brillouin spectroscopy, Raman spectroscopy and polarization-sensitive optical coherence tomography.Frontiers in bioengineering and biotechnology · 2025Article
- Harnessing quantum light for microscopic biomechanical imaging of cells and tissues.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Determining the Relationship Between Corneal Stiffening and Tissue Dehydration After Corneal Cross-Linking.Investigative ophthalmology & visual science · 2024Article
- A Brillouin microscopy analysis of the crystalline lenses of Chinese adults with myopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Article
- Review
- In vivo measurement of the biomechanical properties of human skin with motion-corrected Brillouin microscopy.Biomedical optics express · 2024Article
- In Vivo Evaluation of Corneal Biomechanics Following Cross-Linking Surgeries Using Optical Coherence Elastography in a Rabbit Model of Keratoconus.Translational vision science & technology · 2024Article
- Progressive alteration of murine bladder elasticity in actinic cystitis detected by Brillouin microscopy.Scientific reports · 2024Article
- Brillouin microscopy.Nature reviews. Methods primers · 2024Article
- Multimodal diagnostics for keratoconus and ectatic corneal diseases: a paradigm shift.Eye and vision (London, England) · 2023Review
- Motion-Tracking Brillouin Microscopy Evaluation of Normal, Keratoconic, and Post-Laser Vision Correction Corneas.American journal of ophthalmology · 2023Article
- Evaluation of Eyelid, Angle, and Anterior Segment Parameters Using Scheimpflug Camera and Topography System in Obstructive Sleep Apnea Syndrome.Beyoglu eye journal · 2023Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Purpose: To investigate how corneal hydration affects the Brillouin frequency of corneal stroma. Methods: From a simple analytical model considering the volume fraction of water in corneal stroma, we derived the dependence of Brillouin frequency on hydration and hydration-induced corneal thickness variation. The Brillouin frequencies of fresh ex vivo porcine corneas were measured as their hydration was varied in dextran solution and water. Healthy volunteers (8 eyes) were scanned in vivo repeatedly over the course of 9 hours, and the diurnal variations of Brillouin frequency and central corneal thickness (CCT) were measured. Results: The measured dependence of Brillouin frequency on hydration, both ex vivo and in vivo, agreed well with the theoretical prediction. The Brillouin frequencies of human corneas scanned immediately after waking were on average ∼25 MHz lower than their daytime average values. For stabilized corneas, the typical variation of Brillouin frequency was ± 7.2 MHz. With respect to CCT increase or swelling, the Brillouin frequency decreased with a slope of -1.06 MHz/μm in vivo. Conclusions: The ex vivo and in vivo data agree with our theoretical model and support that the effect of corneal hydration on Brillouin frequency comes predominantly from the dependence of the tissue compressibility on the water. Corneal hydration correlates negatively with the Brillouin frequency. During daytime activities, the influence of physiological hydration changes in human corneas is < ± 10 MHz. The sensitivity to hydration may potentially be useful in detecting abnormal hydration change in patients with endothelial disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.