Evidence map›Paper›PMID 30024943›Full record

ArticlePloS one2018

The draft genomes of Elizabethkingia anophelis of equine origin are genetically similar to three isolates from human clinical specimens.

William L Johnson, Akhilesh Ramachandran, Nathanial J Torres, Ainsley C Nicholson, Anne M Whitney, Melissa Bell, Aaron Villarma, Ben W Humrighouse, Mili Sheth, Scot E Dowd and 2 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. A Genetic Locus inAntibiotics (Basel, Switzerland) · 2024
    Article
  3. Article
  4. A 13-year retrospective study of equine abortions in Canada.The Canadian veterinary journal = La revue veterinaire canadienne · 2022
    Article
  5. Antimicrobial Resistance and Comparative Genomic Analysis ofAntibiotics (Basel, Switzerland) · 2022
    Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

William L JohnsonDepartment of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma, United States of America.ORCID 0000-0003-2616-2553
Akhilesh RamachandranOklahoma Animal Disease Diagnostic Laboratory, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma, United States of America.
Nathanial J TorresDepartment of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma, United States of America.
Ainsley C NicholsonSpecial Bacteriology Reference Laboratory, Bacterial Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
Anne M WhitneySpecial Bacteriology Reference Laboratory, Bacterial Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
Melissa BellSpecial Bacteriology Reference Laboratory, Bacterial Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
Aaron VillarmaSpecial Bacteriology Reference Laboratory, Bacterial Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
Ben W HumrighouseSpecial Bacteriology Reference Laboratory, Bacterial Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
Mili ShethDivision of Scientific Resources, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
Scot E DowdMolecular Research DNA Laboratory, Shallowater, Texas, United States of America.
John R McQuistonSpecial Bacteriology Reference Laboratory, Bacterial Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
John E GustafsonDepartment of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma, United States of America.ORCID 0000-0002-1870-6912
Centers for Disease Control and Prevention · USOklahoma State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the isolation and characterization of two Elizabethkingia anophelis strains (OSUVM-1 and OSUVM-2) isolated from sources associated with horses in Oklahoma. Both strains appeared susceptible to fluoroquinolones and demonstrated high MICs to all cell wall active antimicrobials including vancomycin, along with aminoglycosides, fusidic acid, chloramphenicol, and tetracycline. Typical of the Elizabethkingia, both draft genomes contained multiple copies of β-lactamase genes as well as genes predicted to function in antimicrobial efflux. Phylogenetic analysis of the draft genomes revealed that OSUVM-1 and OSUVM-2 differ by only 6 SNPs and are in a clade with 3 strains of Elizabethkingia anophelis that were responsible for human infections. These findings therefore raise the possibility that Elizabethkingia might have the potential to move between humans and animals in a manner similar to known zoonotic pathogens.

Indexed as

Genetic VariationAnimalsAnti-Bacterial AgentsFlavobacteriaceaeFlavobacteriaceae InfectionsGenes, BacterialGenome, BacterialHorse DiseasesHorsesHost SpecificityHumansMicrobial Sensitivity TestsPhylogenySequence Analysis, DNASpecies SpecificityAnti-Bacterial Agents

Identifiers

PMID30024943
PMCPMC6053191
OpenAlexW2883021756

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.