ArticlePloS one2018
Molecular and antigenic characterization of group C orthobunyaviruses isolated in Peru.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Arthropod-Borne and Rodent-Borne Infections in Peru From 1990 to 2022.The Journal of infectious diseases · 2025Article
- [Key clinical manifestations to differentiate Oropouche fever from dengue and other arboviral diseases: a living systematic reviewRevisão sistemática viva das manifestações clínicas da febre do Oropouche: características-chave para diferenciá-la da dengue e de outras arboviroses].Revista panamericana de salud publica = Pan American journal of public health · 2024Article
- Detection of Zika Virus in Oropharyngeal Swabs from Patients with Acute Febrile Illness.The American journal of tropical medicine and hygiene · 2022Article
- Evaluation of Two Serological Assays for Diagnosing Zika Virus Infection.Diagnostics (Basel, Switzerland) · 2021Article
- Vector Competence of Peruvian Mosquitoes for Two Orthobunyaviruses Isolated From Mosquitoes Captured in Peru.Journal of medical entomology · 2021Article
- Genomic characterization of 99 viruses from the bunyavirus families Nairoviridae, Peribunyaviridae, and Phenuiviridae, including 35 previously unsequenced viruses.PLoS pathogens · 2021Article
- Clinical manifestations of Oropouche virus infection: A systematic review and meta-analysis.Medicine internationalArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Group C orthobunyaviruses (GRCVs) are a complex of viruses in the genus Orthobunyavirus and are associated with human febrile disease in tropical and subtropical areas of South and Central America. While numerous GRCVs have been isolated from mosquitoes, animals, and humans, genetic analysis of these viruses is limited. In this study, we characterized 65 GRCV isolates from febrile patients identified through clinic-based surveillance in the northern and southern Peruvian Amazon. A 500 base pair region of the S segment and 750 base pair regions of the M and L segments were sequenced. Pairwise sequence analysis of the clinical isolates showed nucleotide identities ranging from 68% to 100% and deduced amino acid sequence identities ranging from 72% to 100%. Sequences were compared with reference strains of the following GRCVs: Caraparu virus (CARV), Murutucu virus (MURV), Oriboca virus (ORIV), Marituba virus (MTBV), Itaqui virus (ITQV), Apeu virus (APEUV), and Madrid virus (MADV). Sequence comparison of clinical isolates with the prototype strains based on the S and L segments identified two clades; clade I included isolates with high genetic association with CARV-MADV, and clade II included isolates with high genetic association with MURV, ORIV, APEUV, and MTBV. Genetic relationships based on the M segment were at time inconsistent with those based on the S and L segments. However, clade groupings based on the M segment were highly consistent with relationships based on microneutralization assays. These results advance our understanding of the genetic and serologic relationships of GRCVs circulating in the Peruvian Amazon.
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