ArticleeLife2018
The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation
Open access · goldAbstract read
In one paragraph
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 85 citations in OpenAlex.
- Leptin promotes endothelial dysfunction in chronic kidney disease by modulating the MTA1-mediated WNT/β-catenin pathway.Molecular and cellular biochemistry · 2020Trial
- Evidence for an early cadherin-catenin interaction network in ctenophores.Molecular biology and evolution · 2026Article
- Actomyosin contractility is a potent suppressor of mesoderm induction by human pluripotent stem cells.The Journal of cell biology · 2026Article
- Cell Mechanics in Cancer: Integrating Mechanotransduction Pathways Within the Tumor Microenvironment.Journal of cellular physiology · 2026Review
- A Pathogenic ROCK-Signaling Network Involving a Lysine Deletion in Myh11 Renders Carriers Susceptible to Aortic Dissection.International journal of molecular sciences · 2026Article
- Intact Mass Profiling Reveals Phospho-Proteoforms of the Catenins (85-110 kDa) Regulated by Actomyosin Contractility.Angewandte Chemie (International ed. in English) · 2025Article
- A conformational change in α-catenin's actin-binding domain governs adherens junction maturation.Communications biology · 2025Article
- β-Catenin localization in the ctenophore Mnemiopsis leidyi suggests an ancestral role in cell adhesion and nuclear function.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- Dynamic Remodeling of Mechano-Sensing Complexes in Suspended Fibroblast Cell-Sheets Under External Mechanical Stimulus.Biotechnology and bioengineering · 2025Article
- Acoustic-pressure-driven ultrasonic activation of the mechanosensitive receptor RET and of cell proliferation in colonic tissue.Nature biomedical engineering · 2025Article
- Review
- SHP2 promotes the epithelial-mesenchymal transition in triple negative breast cancer cells by regulating β-catenin.Journal of cancer research and clinical oncology · 2025Article
- Role of the Wnt/β-catenin signaling pathway in the development of HCC.Frontiers in immunology · 2025Review
- Mechanical induction in metazoan development and evolution: from earliest multi-cellular organisms to modern animal embryos.Nature communications · 2024Review
- Mechanical models and measurement methods of solid stress in tumors.Applied microbiology and biotechnology · 2024Review
- A computational study for understanding the impact of p120-catenin on the cis-dimerization of cadherin.Journal of molecular cell biology · 2024Article
- Extracellular Matrix Cues Regulate Mechanosensing and Mechanotransduction of Cancer Cells.Cells · 2024Review
- The Interaction of Mechanics and the Hippo Pathway inCancers · 2023Article
- Tumour follower cells: A novel driver of leader cells in collective invasion (Review).International journal of oncology · 2023Review
- Cardiac fibroblasts and mechanosensation in heart development, health and disease.Nature reviews. Cardiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Jens-Christian RöperMechanics and Genetics of Embryonic and Tumoral Development, Institut Curie, INSERM, CNRS UMR 168, PSL University, Paris, France.
Démosthène Mitrossilis *Mechanics and Genetics of Embryonic and Tumoral Development, Institut Curie, INSERM, CNRS UMR 168, PSL University, Paris, France.ORCID 0000-0003-3382-296X
Guillaume Stirnemann *CNRS Laboratoire de Biochimie Théorique, Institut de Biologie Physico-Chimique, PSL University, Paris, France.
François WaharteSpace-Time Imaging of Endomembranes Dynamics, Cell and Tissue Imaging Facility, Institut Curie, CNRS UMR 144, PSL University, Inria, France.
Isabel BritoCBIO-Centre for Computational Biology, MINES ParisTech, Institut Curie, INSERM, PSL University, Paris, France.
Maria-Elena Fernandez-SanchezMechanics and Genetics of Embryonic and Tumoral Development, Institut Curie, INSERM, CNRS UMR 168, PSL University, Paris, France.
Marc BaadenCNRS Laboratoire de Biochimie Théorique, Institut de Biologie Physico-Chimique, PSL University, Paris, France.ORCID 0000-0001-6472-0486
Jean SalameroSpace-Time Imaging of Endomembranes Dynamics, Cell and Tissue Imaging Facility, Institut Curie, CNRS UMR 144, PSL University, Inria, France.
Emmanuel FargeMechanics and Genetics of Embryonic and Tumoral Development, Institut Curie, INSERM, CNRS UMR 168, PSL University, Paris, France.ORCID 0000-0002-5063-7179
Centre National de la Recherche Scientifique · FRInserm · FR
Funding
Agence Nationale de la Recherche 11 BSV5014-01Agence Nationale de la Recherche 11-LBX-0038Agence Nationale de la Recherche ANR-10-INBS-04Agence Nationale de la Recherche ANR-11-LABX-0011-01European Commission PIEF-GA-2012-332422Fondation pour la Recherche Médicale DEQ20150331702
Abstract
PubMed holds no abstract for this paper.
Indexed as
Cell DifferentiationAmino Acid SequenceAnimalsArmadillo Domain ProteinsBinding SitesCadherinsDrosophila melanogasterDrosophila ProteinsFluorescence Resonance Energy TransferMechanotransduction, CellularMolecular Dynamics SimulationPhosphorylationProtein BindingProtein ConformationProto-Oncogene Proteins pp60(c-src)Sequence HomologyArmadillo Domain ProteinsARM protein, DrosophilaCadherinsDrosophila ProteinsProto-Oncogene Proteins pp60(c-src)shg protein, DrosophilaSrc42A protein, DrosophilaTranscription Factorsbeta-cateninbiochemistrychemical biologydevelopmental biologyD. melanogasterFRET-FLIMgastrulationmechanotransductionmolecular dynamic simulations
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.