ArticleGut microbes2018
Bifidobacterium animalis subspecies lactis modulates the local immune response and glucose uptake in the small intestine of juvenile pigs infected with the parasitic nematode Ascaris suum.
Article in Gut microbes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Systematic review of animal-based indicators to measure thermal, social, and immune-related stress in pigs.PloS one · 2022Pooled it
- Article
- Fermentable fiber supplementation in pigs promotes anti-parasitic defense mechanisms and impacts parasite growth inFrontiers in immunology · 2026Article
- AdultCurrent research in parasitology & vector-borne diseases · 2026Article
- Infection with gut parasites correlates with gut microbiome diversity across human populations in Africa.Gut microbes · 2025Article
- Comparative Genomics Analysis Combined with Homologous Overexpression Reveals the Mechanism of Species-Specific Acid Stress Resistance inFoods (Basel, Switzerland) · 2025Article
- Peroxisome Proliferator-Activated Receptors (PPARs) May Mediate the Neuroactive Effects of Probiotic Metabolites: An In Silico Approach.International journal of molecular sciences · 2025Article
- Alleviating peripartum oxidative stress and enhancing maternal behavior in loose-housed hyperprolific sows improves the farrowing process and piglet performance: effects of ferulic acid, probiotic mixture, or jute sacks.Journal of animal science · 2025Article
- Probiotics: an alternative anti-parasite therapy.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024Review
- Profiling the Gut Microbiota in Obese Children with Formula Feeding in Early Life and Selecting Strains against Obesity.Foods (Basel, Switzerland) · 2024Article
- Elevated circulating group-2 innate lymphoid cells expressing activation markers and correlated tryptase AB1 levels in active ascariasis.Frontiers in immunology · 2024Article
- Combined supplementation with Lactobacillus sp. and Bifidobacterium thermacidophilum isolated from Tibetan pigs improves growth performance, immunity, and microbiota composition in weaned piglets.Journal of animal science · 2023Article
- Exploring the underlying mechanisms of obesity and diabetes and the potential of Traditional Chinese Medicine: an overview of the literature.Frontiers in endocrinology · 2023Review
- Modulation of the porcine intestinal microbiota in the course of Ascaris suum infection.Parasites & vectors · 2022Article
- Article
- Changes in porcine nutrient transport physiology in response to Ascaris suum infection.Parasites & vectors · 2021Article
- Local intestinal microbiota response and systemic effects of feeding black soldier fly larvae to replace soybean meal in growing pigs.Scientific reports · 2021Article
- Emerging interactions between diet, gastrointestinal helminth infection, and the gut microbiota in livestock.BMC veterinary research · 2021Review
- Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review.Frontiers in immunology · 2021Review
- Searching for the one(s): Using Probiotics as Anthelmintic Treatments.Frontiers in pharmacology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An evaluation of a localized intestinal allergic type-2 response concomitant with consumption of probiotic bacteria is not well documented. This study investigated the effect of feeding probiotic Bifidobacterium animalis subspecies lactis (Bb12) or a placebo in weaned pigs that were also inoculated with Ascaris suum (A. suum) eggs to induce a strong Th2-dependent allergic type 2 immune response. Sections of jejunal mucosa were mounted in Ussing chambers to determine changes in permeability and glucose absorption, intestine and liver samples were collected for analysis of type-2 related gene expression, jejunum examined histologically, and sera and intestinal fluid were assayed for parasite antigen specific antibody. The prototypical parasite-induced secretory response to histamine and reduced absorption of glucose in the jejunum were attenuated by feeding Bb12 without a change in mucosal resistance. Parasite antigen-specific IgA response in the serum and IgG1 and IgG2 response in the ileal fluid were significantly increased in A. suum-infected pigs treated with Bb12 compared to infected pigs given the placebo. Ascaris suum-induced eosinophilia in the small intestinal mucosa was inhibited by Bb12 treatment without affecting the normal expulsion of A. suum 4th stage larvae (L4) or the morphometry of the intestine. Expression of genes associated with Th1/Th2 cells, Treg cells, mast cells, and physiological function in the intestine were modulated in A. suum infected-pigs treated with Bb12. These results suggested that Bb12 can alter local immune responses and improve intestinal function during a nematode infection by reducing components of a strong allergenic type-2 response in the pig without compromising normal parasite expulsion.
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Registered trials
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