ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2018
Regulation of amniotic fluid volume: insights derived from amniotic fluid volume function curves.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- The Impact of a Low-Glucose Diet on Amniotic Fluid Index in Pregnant Women with Idiopathic Polyhydramnios: A Clinical Trial : Low-Glucose Diet and Amniotic Fluid Index in Pregnant Women.Galen medical journal · 2025Article
- Foetal gluten immunogenic peptides during pregnancy: a new determinant on the coeliac exposome.BMC medicine · 2024Article
- Isolated polyhydramnios in the third trimester or polyhydramnios secondary to late-onset gestational diabetes: is it worth distinguishing?Revista da Associacao Medica Brasileira (1992) · 2024Article
- Discrimination of blood metabolomics profiles in neonates with idiopathic polyhydramnios.European journal of pediatrics · 2023Article
- Article
- Amniotic Fluid Disorders: From Prenatal Management to Neonatal Outcomes.Children (Basel, Switzerland) · 2023Review
- Aquaporins in Fetal Development.Advances in experimental medicine and biology · 2023Article
- Changes in the morphometry of the uterus, ovary, and foetus, and biochemistry of allantoic and amniotic membrane fluids of Yankasa ewes across the gestation period.Tropical animal health and production · 2021Article
- Antimicrobial Activity of Human Fetal Membranes: From Biological Function to Clinical Use.Frontiers in bioengineering and biotechnology · 2021Review
- Altered proteomics profile in the amnion of patients with oligohydramnios.Physiological reports · 2020Article
- Multiomics analyses of vesicular transport pathway-specific transcripts and proteins in ovine amnion: responses to altered intramembranous transport.Physiological genomics · 2019Article
- Intrapartum Results on Differing Degrees of Ketonuria in Nulliparous Women with Gestational Diabetes Mellitus during Spontaneous Labor.International journal of endocrinology · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Recent advances in understanding the regulation of amniotic fluid volume (AFV) include that AFV is determined primarily by the rate of intramembranous absorption (IMA) of amniotic fluid across the amnion and into fetal blood. In turn, IMA rate is dependent on the concentrations of yet-to-be identified stimulator(s) and inhibitor(s) that are present in amniotic fluid. To put these concepts in perspective, this review 1) discusses the evolution of discoveries that form the current basis for understanding the regulation of AFV, 2) reviews the contribution of IMA to this regulation, and 3) interprets experimentally induced shifts in AFV function curves and amnioinfusion function curves in terms of the activity of the amniotic fluid stimulator and inhibitor of IMA. In the early 1980s, it was not known whether AFV was regulated. However, by the late 1980s, IMA was discovered to be a "missing link" in understanding the regulation of AFV. Over the next 25 years the concept of IMA evolved from being a passive process to being an active, unidirectional transport of amniotic fluid water and solutes by vesicles within the amnion. In the 2010s, it was demonstrated that a renally derived stimulator and a fetal membrane-derived inhibitor are present in amniotic fluid that regulate IMA rate and hence are the primary determinants of AFV. Furthermore, AFV function curves and amnioinfusion function curves provide new insights into the relative efficacy of the stimulator and inhibitor of IMA.
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