ReviewMass spectrometry reviews2020
The integration of LC-MS and NMR for the analysis of low molecular weight trace analytes in complex matrices.
Review in Mass spectrometry reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- Discovery urinary metabolomics of preterm neonatal acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Advantages of a Multi-Platform Workflow Integrating Biphasic Extraction, Chromatography, and NMR for Characterization of Metabolites in Extracts ofMetabolites · 2026Article
- Artificial intelligence in impurity prediction: current landscape, challenges, and future directions.Journal of computer-aided molecular design · 2026Review
- Enzymatically hydrolyzed oligosaccharide fingerprinting using nanopipettes at the single-molecule level.Chemical science · 2026Article
- From night hormone to green signal: The journey of melatonin.Protoplasma · 2026Review
- Advanced technologies of single-cell metabolomics unveiling cellular metabolic heterogeneity for biological and biomedical research.Journal of food and drug analysis · 2026Review
- Impurity Characterization Across Drug Development Stages: Analytical Methodologies and Regulatory Perspectives.Pharmaceutical research · 2026Review
- Liquid Chromatography-Mass Spectrometry-Based Molecular Profiling of Vertigoheel.International journal of molecular sciences · 2026Article
- Lipid metabolic plasticity in glioblastoma: mechanisms, tumor microenvironment remodeling, and therapeutic opportunities.Frontiers in oncology · 2026Review
- Bacterial secondary metabolites as resistance-modifying adjuvants: microbial origins, molecular mechanisms, and translational relevance.Frontiers in microbiology · 2026Review
- Gas Chromatography-Mass Spectrometry (GC-MS) in the Plant Metabolomics Toolbox: Sample Preparation and Instrumental Analysis.Biomolecules · 2025Review
- The lysine degradation pathway analyzed withRSC advances · 2025Article
- Bioactive compounds from marine algae in pancreatic cancer therapy: mechanistic insights into fucoidan and phlorotannins: a review.Medical oncology (Northwood, London, England) · 2025Review
- Chemical Profiling and Quality Assessment of Food Products Employing Magnetic Resonance Technologies.Foods (Basel, Switzerland) · 2025Review
- Micro- and Nanoengineered Devices for Rapid Chemotaxonomic Profiling of Medicinal Plants.Nanomaterials (Basel, Switzerland) · 2025Review
- Comparison of Vegetable Waste Byproducts of Selected Cultivars of Foeniculum vulgare Mill. by an Integrated LC-(HR)MS andPhytochemical analysis : PCA · 2025Article
- Harnessing NMR technology for enhancing field crop improvement: applications, challenges, and future perspectives.Metabolomics : Official journal of the Metabolomic Society · 2025Review
- Ethnobotany, phytochemistry, pharmacology and toxicity ofFrontiers in pharmacology · 2025Review
- Evaluation of Tuina Combined with Medicated Oil in Non-Specific Low Back Pain Treatment: A Randomized Clinical Trial.Journal of pain research · 2025Article
- The Metabolomic Footprint of Liver Fibrosis.Cells · 2024Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
This review discusses the integration of liquid chromatography (LC), mass spectrometry (MS), and nuclear magnetic resonance (NMR) in the comprehensive analysis of small molecules from complex matrices. We first discuss the steps taken toward making the three technologies compatible, so as to create an efficient analytical platform. The development of online LC-MS-NMR, highlighted by successful applications in the profiling of highly concentrated analytes (LODs 10 μg) is discussed next. This is followed by a detailed overview of the alternative approaches that have been developed to overcome the challenges associated with online LC-MS-NMR that primarily stem from the inherently low sensitivity of NMR. These alternative approaches include the use of stop-flow LC-MS-NMR, loop collection of LC peaks, LC-MS-SPE-NMR, and offline NMR. The potential and limitations of all these approaches is discussed in the context of applications in various fields, including metabolomics and natural product discovery.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.