ArticleRetina (Philadelphia, Pa.)2019
AMPLITUDE LOSS OF THE HIGH-FREQUENCY FLICKER ELECTRORETINOGRAM IN EARLY DIABETIC RETINOPATHY.
Article in Retina (Philadelphia, Pa.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Novel Detection and Restorative Levodopa Treatment for Preclinical Diabetic Retinopathy.Diabetes · 2020Trial
- Everolimus suppresses glucose transporter 3 membrane trafficking to improve therapeutic efficacy of umbilical cord blood-derived mesenchymal stem cell transplantation in diabetic retinopathy.Cell death & disease · 2026Article
- Selecting measures of visual function to classify diabetic retinopathy status: a cross-sectional study.BMJ open ophthalmology · 2026Article
- Brief report: harmonic analysis of the 30 Hz flicker ERG in early-stage diabetic retinopathy.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Efficacy of Subconjunctivally Applied Everolimus- and Sirolimus-Pretreated MSCs in Preventing Diabetic Retinopathy.Translational vision science & technology · 2025Article
- Early detection of retinal dysfunction in type 1 diabetes without retinopathy using multifocal electroretinography.Scientific reports · 2025Observational
- The effects of time restricted feeding on age-related changes in the mouse retina.Experimental gerontology · 2024Article
- Retinal Function in Long-Term Type 1 Diabetes without Retinopathy: Insights from Pattern Electroretinogram and Pattern Visual Evoked Potentials Assessments.Diagnostics (Basel, Switzerland) · 2024Article
- Electrophysiological findings in long-term type 1 diabetes patients without diabetic retinopathy using different ERG recording systems.Scientific reports · 2024Article
- Retinal Functional Impairment in Diabetic Retinopathy.Biomedicines · 2023Article
- Rod photoreceptor activation and deactivation in early-stage diabetic eye disease.Documenta ophthalmologica. Advances in ophthalmology · 2023Article
- Effects of normal aging on the mouse retina assessed by full-field flash and flicker electroretinography.Scientific reports · 2023Article
- Towards a New Biomarker for Diabetic Retinopathy: Exploring RBP3 Structure and Retinoids Binding for Functional Imaging of Eyes In Vivo.International journal of molecular sciences · 2023Review
- Full-field and multifocal electroretinogram in non-diabetic controls and diabetics with and without retinopathy.Acta ophthalmologica · 2022Article
- Preventing diabetic retinopathy by mitigating subretinal space oxidative stressVisual neuroscience · 2020Review
- Characterizing the Retinal Phenotype in the High-Fat Diet and Western Diet Mouse Models of Prediabetes.Cells · 2020Article
- Electrophysiological measures of dysfunction in early-stage diabetic retinopathy: No correlation between cone phototransduction and oscillatory potential abnormalities.Documenta ophthalmologica. Advances in ophthalmology · 2020Article
- Electrophysiological and pupillometric measures of inner retina function in nonproliferative diabetic retinopathy.Documenta ophthalmologica. Advances in ophthalmology · 2019Article
- Nonlinearities in the flicker electroretinogram: A tool for studying retinal dysfunction applied to early-stage diabetic retinopathy.Vision research · 2019Article
- Cone Photoreceptor Dysfunction in Early-Stage Diabetic Retinopathy: Association Between the Activation Phase of Cone Phototransduction and the Flicker Electroretinogram.Investigative ophthalmology & visual science · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo evaluate retinal dysfunction in diabetic patients who have mild or no nonproliferative diabetic retinopathy (DR) using the high-frequency flicker electroretinogram.
methodsLight-adapted flicker electroretinograms were recorded from 15 diabetic patients who have no clinically apparent retinopathy, 15 diabetic patients who have mild nonproliferative DR, and 15 nondiabetic, age-equivalent controls. Electroretinograms were elicited by full-field flicker at 2 temporal frequencies, 31.25 and 62.5 Hz, and were recorded using conventional techniques. Amplitude and timing of the flicker responses were compared among the groups and correlated with clinical characteristics including age, acuity, disease duration, and HbA1c.
resultsThe 31.25-Hz flicker amplitude was slightly, but nonsignificantly, smaller for subjects with no DR and mild nonproliferative DR , compared with the control group (both t < 1.38, P > 0.31); small, nonsignificant response delays for both patient groups were also observed (both t < 1.57, P > 0.12). By contrast, there were significant amplitude reductions for the 62.5-Hz flicker stimulus: mean amplitude was reduced by 32% for subjects with no DR and by 41% for subjects with mild nonproliferative DR (both t > 2.92 and P < 0.01). Response timing at 62.5 Hz did not differ significantly from control for either group (both t < 1.2 and P > 0.39). Electroretinogram amplitude and timing were not correlated significantly with clinical characteristics.
conclusionThe 62.5-Hz flicker electroretinogram is useful for evaluating retinal dysfunction in diabetic patients who have mild or no DR because this response can be significantly reduced. Attenuation of the high-frequency flicker electroretinogram, which is primarily generated by bipolar cells, suggests a relatively early retinal site of neural dysfunction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.