SynthesisMedicine2018
A meta-analysis supports core needle biopsy by radiologists for better histological diagnosis in soft tissue and bone sarcomas.
Synthesis in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Diagnosis and Therapy of Soft Tissue Sarcomas: Spanish Group for Research in Sarcomas (GEIS) Guidelines.Cancers · 2025Guideline
- ISUOG/ESGO Consensus Statement on ultrasound-guided biopsy in gynecological oncology.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Guideline
- Clinical practice guidelines for the treatment of Ewing sarcoma (Spanish Sarcoma Research Group-GEIS).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Guideline
- Diagnostic yield of percutaneous core needle biopsy in suspected soft tissue lesions of extremities.The Journal of international medical research · 2019Trial
- Histopathological features of chest wall masses: a systematic review.Annals of medicine and surgery (2012) · 2025Article
- Bone Biopsies: Practical Considerations and Technical Tips.Seminars in interventional radiology · 2024Review
- Diagnostic efficacy of image-guided core needle biopsy of suspected malignant osseous lesions: a retrospective cohort study from a single academic institution.European radiology · 2024Article
- Factors affecting the success of CT-guided core biopsy of musculoskeletal lesions with a 13-G needle.Skeletal radiology · 2024Article
- A Review of Core Biopsies in Musculoskeletal Oncology.Indian journal of surgical oncology · 2024Review
- Analysis on diagnostic failure of US-guided core needle biopsy for soft tissue tumors.Research in diagnostic and interventional imaging · 2023Article
- Primary thyroid chondrosarcoma: a case report of an extremely rare malignancy.Journal of the Egyptian National Cancer Institute · 2022Article
- Ultrasound-Guided Trans-Uterine Cavity Core Needle Biopsy of Uterine Myometrial Tumors to Differentiate Sarcoma from a Benign Lesion-Description of the Method and Review of the Literature.Diagnostics (Basel, Switzerland) · 2022Review
- Accuracy of core needle biopsy for histologic diagnosis of soft tissue sarcoma.Scientific reports · 2022Article
- Article
- Percutaneous Image-guided Needle Biopsy of Musculoskeletal Tumors: Technical Tips.Interventional radiology (Higashimatsuyama-shi (Japan) · 2021Review
- Diagnostic accuracy of ultrasound-guided core needle biopsy versus incisional biopsy in soft tissue sarcoma: an institutional experience.Scientific reports · 2021Article
- Percutaneous Core Needle Biopsy Can Efficiently and Safely Diagnose Most Primary Bone Tumors.Diagnostics (Basel, Switzerland) · 2021Article
- Validity of negative bone biopsy in suspicious bone lesions.Acta radiologica open · 2021Article
- Contrast-enhanced ultrasound-guided musculoskeletal biopsies: our experience and technique.Skeletal radiology · 2021Article
- Application of modified closed biopsy in rabbit model of VX2-transplanted bone tumor.Journal of orthopaedic surgery and research · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough surgical biopsy has historically been considered to be the standard diagnostic biopsy for soft tissue and bone sarcomas, recent literature suggests that percutaneous core needle biopsy yields similar results. Therefore, an evaluation of the exact diagnostic accuracy and associated influential variables of core needle biopsy that is based on a large data set would be useful.
methodsWe searched MEDLINE, Web of Science, and EMBASE to identify core needle biopsy studies for predicting final histological subtypes of musculoskeletal lesions. The diagnostic accuracies of core needle biopsy and of surgical biopsy were assessed and compared by using random-effect meta-analyses. The factors relevant to diagnostic accuracy were evaluated by meta-regression and subgroup analyses.
resultsWe selected 32 studies comprising 7209 musculoskeletal lesions. The pooled proportion estimate for the diagnostic accuracy of core needle biopsy was 0.84 (95% confidential interval, CI: 0.81-0.87), which indicated an approximate 84% concordance between core needle biopsy results and final histological diagnoses. The findings of meta-regression and subgroup analyses suggested that radiologists were better core needle biopsy operators than surgeons. An additional meta-analysis for direct comparison between core needle biopsy and surgical biopsy demonstrated that diagnostic accuracy was significantly lower for core needle biopsy than for surgical (pooled odds ratio: 0.39, 95% CI: 0.20-0.76).
conclusionOur results suggested that core needle biopsy should be performed by expert radiologists and that surgical biopsy should be performed if diagnosis following core needle biopsy does not match the clinical presentation and radiographic findings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.