Evidence map›Paper›PMID 30024437›Full record

ArticleCancer nursing

Morning Fatigue Severity Profiles in Oncology Outpatients Receiving Chemotherapy.

Fay Wright, Laura B Dunn, Steven M Paul, Yvette P Conley, Jon D Levine, Marilyn J Hammer, Bruce A Cooper, Christine Miaskowski, Kord M Kober

Abstract read
In one paragraph

Article in Cancer nursing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Trial
  2. Joint nausea and fatigue profiles during chemotherapy identify patients with a higher symptom burden.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Prediction of morning fatigue severity in outpatients receiving chemotherapy: less may still be more.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  10. Article
  11. Impact of worst pain severity and morning fatigue profiles on oncology outpatients' symptom burden and quality of life.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  12. Cumulative burden of symptomatology in patients with gynecologic malignancies undergoing chemotherapy.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2022
    Article
  13. Article
  14. Article
  15. Subgroups of patients undergoing chemotherapy with distinct cognitive fatigue and evening physical fatigue profiles.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Article
  16. Distinct profiles of multiple co-occurring symptoms in patients with gastrointestinal cancers receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Article
  17. Article
  18. Higher levels of stress and different coping strategies are associated with greater morning and evening fatigue severity in oncology patients receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fay WrightAuthor Affiliations: School of Nursing, Yale University (Dr Wright), New Haven, Connecticut; School of Medicine, Stanford University (Dr Dunn), Palo Alto, California; School of Nursing, University of California (Drs Paul, Cooper, Miaskowski, and Kober), San Francisco; School of Nursing, University of Pittsburgh (Dr Conley), Pennsylvania; School of Medicine, University of California (Dr Levine), San Francisco; and Mount Sinai Medical Center (Dr Hammer), New York, New York.
Laura B Dunn
Steven M Paul
Yvette P Conley
Jon D Levine
Marilyn J Hammer
Bruce A Cooper
Christine Miaskowski
Kord M Kober

Funding

Symptoms Clusters in Oncology Patients Receiving ChemotherapyR01CA134900 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, MIASKOWSKI, CHRISTINE A. · 2009 to 2014
$5.9M
Research Training: Self and Family ManagementT32NR008346 · NINR · YALE UNIVERSITY · PI GREY, MARGARET · 2003 to 2018
$4.7M
Advancing the Science of Symptom Management in Oncology PatientsK05CA168960 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 2013 to 2017
$453k
NCI NIH HHS K05 CA168960NCI NIH HHS R01 CA134900NINR NIH HHS T32 NR008346
6 · The paper itself

Abstract

backgroundMorning fatigue is a distinct symptom experienced during chemotherapy that demonstrates significant interindividual variability.

objectivesThe aims of this study were to identify subgroups with distinct morning fatigue profiles and evaluate how these subgroups differed by demographic, clinical, and symptom characteristics.

methodsOutpatients (N = 1332) with breast, gastrointestinal, gynecological, or lung cancer completed questionnaires 6 times over 2 cycles of chemotherapy. Morning fatigue was assessed with the Lee Fatigue Scale. Latent profile analysis was used to identify distinct morning fatigue profiles.

resultsFour morning fatigue profiles (ie, very low, low, high, and very high) were identified. In the high and very high classes, all 6 morning fatigue scores were higher than the clinical cutoff score. Compared with those in the very low and low classes, patients in the very high class were younger and not married/partnered; lived alone; had higher incomes, higher comorbidity, and higher body mass index; and did not exercise regularly. Across the 4 classes, functional status and attentional function scores decreased and anxiety, depression, sleep disturbance, morning fatigue, and evening fatigue scores increased across the 2 cycles.

conclusionResults provide insights into modifiable risk factors for morning fatigue. These risk factors can be used to develop more targeted interventions. IMPLICATIONS FOR PRACTICE: Patients in the high and very high morning fatigue classes experienced high symptom and comorbidity burdens and significant decrements in functional status. Using this information, clinicians can identify patients who are at an increased risk for higher levels of morning fatigue and prescribe interventions to improve this devastating symptom.

Indexed as

AdultAgedAged, 80 and overAntineoplastic AgentsFatigueFemaleHumansMaleMiddle AgedNeoplasmsOutpatientsRisk FactorsSeverity of Illness IndexSleep Wake DisordersSurveys and QuestionnairesAntineoplastic Agents

Identifiers

PMID30024437
PMCPMC6336532

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.