Evidence map›Paper›PMID 30024380›Full record

ArticleeLife2018

Importance of miRNA stability and alternative primary miRNA isoforms in gene regulation during

Li Zhou, Mandy Yu Theng Lim, Prameet Kaur, Abil Saj, Diane Bortolamiol-Becet, Vikneswaran Gopal, Nicholas Tolwinski, Greg Tucker-Kellogg, Katsutomo Okamura

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Temporal Expression Analysis to Unravel Gene Regulatory Dynamics by microRNAs.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  5. Review
  6. miRNAs in HCC, pathogenesis, and targets.Hepatology (Baltimore, Md.) · 2024
    Article
  7. Article
  8. Article
  9. A micro-RNA is the effector gene of a classic evolutionary hotspot locus.bioRxiv : the preprint server for biology · 2024
    Article
  10. MicroRNA Targets PAP1 to Mediate Melanization inInternational journal of molecular sciences · 2024
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. In Silico Study of piRNA Interactions with the SARS-CoV-2 Genome.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Li Zhou *Temasek Life Sciences Laboratory, Singapore, Singapore.
Mandy Yu Theng Lim *Temasek Life Sciences Laboratory, Singapore, Singapore.
Prameet KaurDivision of Science, Yale-NUS College, Singapore, Singapore.
Abil SajCancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore, Singapore.
Diane Bortolamiol-BecetDepartment of Developmental Biology, Sloan-Kettering Institute, New York, United States.
Vikneswaran GopalDepartment of Statistics and Applied Probability, Faculty of Science, National University of Singapore, Singapore, Singapore.
Nicholas TolwinskiDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore.
Greg Tucker-KelloggDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore.
Katsutomo OkamuraTemasek Life Sciences Laboratory, Singapore, Singapore.ORCID http://orcid.org/0000-0002-8316-0960
National University of Singapore · SGTemasek Life Sciences Laboratory · SGGenome Institute of Singapore · SGKettering University · USYale-NUS College · SG

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Selective regulatory and biogenesis mechanisms for microRNAsR01GM083300 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Eric C Lai · 2007 to 2026
$9.8M
DROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4M
Mechanism and regulation of Hu family RNA binding proteins during neural alternative polyadenylationR01NS083833 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI LAI, ERIC C · 2014 to 2023
$5.4M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM083300NIH HHS P40 OD010949NIH HHS R01-GM083300NIH HHS R01-NS083833NINDS NIH HHS R01 NS083833
6 · The paper itself

Abstract

Mature microRNAs (miRNAs) are processed from primary transcripts (pri-miRNAs), and their expression is controlled at transcriptional and post-transcriptional levels. However, how regulation at multiple levels achieves precise control remains elusive. Using published and new datasets, we profile a time course of mature and pri-miRNAs in

Indexed as

Gene Expression Regulation, DevelopmentalRNA StabilityAnimalsDrosophilaGene Expression ProfilingMicroRNAsMicroRNAschromosomesclustered miRNA genesD. melanogasterembryogenesisgene expressionmiRNA stability

Identifiers

PMID30024380
PMCPMC6066331
OpenAlexW2884449534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.