Evidence map›Paper›PMID 30024078›Full record

Trial reportNeuromodulation : journal of the International Neuromodulation Society2019

A Feasibility Study of Percutaneous Peripheral Nerve Stimulation for the Treatment of Postoperative Pain Following Total Knee Arthroplasty.

Brian M Ilfeld, Scott T Ball, Rodney A Gabriel, Jacklynn F Sztain, Amanda M Monahan, Wendy B Abramson, Bahareh Khatibi, Engy T Said, Jesal Parekh, Stuart A Grant and 2 more

2 registry-linked trialsOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuromodulation : journal of the International Neuromodulation Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03484429 nacompletednot on this map

Effects of Postoperative Percutaneous Peripheral Nerve Stimulation on Acute and Chronic Amputation Pain

TypeinterventionalSponsorHunter Holmes Mcguire Veteran Affairs Medical CenterRan2017 to 2021Enrolled16ConditionsPhantom Limb Pain, Postoperative Pain, Neuroma, Acute PainArmsPeripheral nerve stimulation, Standard Medical Therapy
NCT04670042 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Feasibility and Effectiveness of Using Peripheral Nerve Stimulation (PNS) to Treat Chronic Post-surgical Pain (CPSP) Following Total Knee Arthroplasty.

TypeinterventionalSponsorStanford UniversityRan2021 to 2024Enrolled0ConditionsInjury, Nerve, Peripheral, Multiple, Chronic Post-Procedural Pain, Total Knee ArthroplastyArmsSPRINT® Peripheral Nerve Stimulation (PNS) System (510k Cleared)
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 106 citations in OpenAlex.

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  15. Peripheral Nervous System Pain Modulation.Current neuropharmacology · 2024
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  18. Programmable Pulse Generator for Pain Relief Stimulation using Bioresorbable Electrodes.IEEE Biomedical Circuits and Systems Conference : healthcare technology : [proceedings]. IEEE Biomedical Circuits and Systems Conference · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Brian M IlfeldDepartment of Anesthesiology, University of California San Diego, San Diego, CA, USA.
Scott T BallDepartment of Orthopaedic Surgery, University of California San Diego, San Diego, CA, USA.
Rodney A GabrielDepartment of Anesthesiology, University of California San Diego, San Diego, CA, USA.
Jacklynn F SztainDepartment of Anesthesiology, University of California San Diego, San Diego, CA, USA.
Amanda M MonahanDepartment of Anesthesiology, University of California San Diego, San Diego, CA, USA.
Wendy B AbramsonDepartment of Anesthesiology, University of California San Diego, San Diego, CA, USA.
Bahareh KhatibiDepartment of Anesthesiology, University of California San Diego, San Diego, CA, USA.
Engy T SaidDepartment of Anesthesiology, University of California San Diego, San Diego, CA, USA.
Jesal ParekhDepartment of Orthopaedic Surgery, University of California San Diego, San Diego, CA, USA.
Stuart A GrantDuke University Medical Center, Duke University, Durham, NC, USA.
Amorn WongsarnpigoonSPR Therapeutics, Cleveland, OH, USA.
Joseph W BoggsSPR Therapeutics, Cleveland, OH, USA.
University of California, San Diego · USSprint PNS System (United States) · USDuke Medical Center · USOutcomes Research Consortium · US

Funding

Electrical stimulation to reduce pain and improve function after knee replacementR44AG052196 · NIA · SPR THERAPEUTICS, LLC · PI BOGGS, JOSEPH WILDER · 2015 to 2023
$4.9M
NIA NIH HHSNIA NIH HHS R44 AG052196NIH HHS R44AG052196SPR Therapeutics
6 · The paper itself

Abstract

introductionThe objective of the present feasibility study was to investigate the use of a new treatment modality-percutaneous peripheral nerve stimulation (PNS)-in controlling the often severe and long-lasting pain following total knee arthroplasty (TKA).

methodsFor patients undergoing a primary, unilateral TKA, both femoral and sciatic open-coil percutaneous leads (SPR Therapeutics, Cleveland, OH) were placed up to seven days prior to surgery using ultrasound guidance. The leads were connected to external stimulators and used both at home and in the hospital for up to six weeks total.

resultsIn six of seven subjects (86%), the average of daily pain scores across the first two weeks was <4 on the 0-10 Numeric Rating Scale for pain. A majority of subjects (four out of seven; 57%) had ceased opioid use within the first week (median time to opioid cessation for all subjects was six days). Gross sensory/motor function was maintained during stimulation, enabling stimulation during physical therapy and activities of daily living. At 12 weeks following surgery, six of seven subjects had improved by >10% on the Six-Minute Walk Test compared to preoperative levels, and WOMAC scores improved by an average of 85% compared to before surgery. No falls, motor block, or lead infections were reported.

conclusionsThis feasibility study suggests that for TKA, ultrasound-guided percutaneous PNS is feasible in the immediate perioperative period and may provide analgesia without the undesirable systemic effects of opioids or quadriceps weakness induced by local anesthetics-based peripheral nerve blocks.

Indexed as

Activities of Daily LivingAgedArthroplasty, Replacement, KneeFeasibility StudiesFemaleHumansMaleMiddle AgedPain MeasurementPostoperative PainProspective StudiesTranscutaneous Electric Nerve StimulationTreatment OutcomeUltrasonography, Interventionalopioid cessationpercutaneous peripheral nerve stimulationPostoperative analgesiatotal knee replacement

Identifiers

PMID30024078
PMCPMC6339601
OpenAlexW2884336369

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.