Evidence map›Paper›PMID 30024066›Full record

ArticleMagnetic resonance in medicine2019

Combined angiography and perfusion using radial imaging and arterial spin labeling.

Thomas W Okell

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  10. Review
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  14. Intracranial 3D and 4D MR Angiography Using Arterial Spin Labeling: Technical Considerations.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2020
    Review
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  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Thomas W OkellWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-8258-0659

Funding

Wellcome Trust 203139/Z/16/Z
6 · The paper itself

Abstract

purposeTo demonstrate the feasibility of a novel noninvasive MRI technique for the comprehensive evaluation of blood flow to the brain: combined angiography and perfusion using radial imaging and arterial spin labeling (CAPRIA).

methodsIn the CAPRIA pulse sequence, blood labeled with a pseudocontinuous arterial spin labeling pulse train is continuously imaged as it flows through the arterial tree and into the brain tissue using a golden ratio radial readout. From a single raw data set, this flexible imaging approach allows the reconstruction of both high spatial/temporal resolution angiographic images with a high undersampling factor and low spatial/temporal resolution perfusion images with a low undersampling factor. The sparse and high SNR nature of angiographic images ensures that radial undersampling artifacts are relatively benign, even when using a simple regridding image reconstruction. Pulse sequence parameters were optimized through sampling efficiency calculations and the numerical evaluation of modified pseudocontinuous arterial spin labeling signal models. A comparison was made against conventional pseudocontinuous arterial spin labeling angiographic and perfusion acquisitions.

results2D CAPRIA data in healthy volunteers demonstrated the feasibility of this approach, with good vessel visualization in the angiographic images and clear tissue perfusion signal when reconstructed at 108-ms and 252-ms temporal resolution, respectively. Images were qualitatively similar to those from conventional acquisitions, but CAPRIA had significantly higher SNR efficiency (48% improvement on average, P = 0.02).

conclusionThe CAPRIA technique shows potential for the efficient evaluation of both macrovascular blood flow and tissue perfusion within a single scan, with potential applications in a range of cerebrovascular diseases.

Indexed as

Cerebral AngiographyMagnetic Resonance AngiographySpin LabelsAdultArteriesArtifactsBrainCerebrovascular CirculationFemaleHumansImage EnhancementImage Processing, Computer-AssistedImaging, Three-DimensionalMaleMiddle AgedPerfusionSpin Labelsarterial spin labelingbrain blood flowdynamic angiographynoncontrastperfusion imagingsimultaneous acquisition

Identifiers

PMID30024066
PMCPMC6282709

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.