Evidence map›Paper›PMID 30023942›Full record

ArticleACS omega2018

Image-Based Tracking of Anticancer Drug-Loaded Nanoengineered Polyelectrolyte Capsules in Cellular Environments Using a Fast Benchtop Mid-Infrared (MIR) Microscope.

Rabah Mouras, Mohamed R Noor, Laura Pastorino, Enrico Bagnoli, Aladin Mani, Edel Durack, Alexei Antipov, Francesca D'Autilia, Paolo Bianchini, Alberto Diaspro and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Rabah MourasDepartment of Physics, Bernal Institute and Department of Chemical Sciences, Bernal Institute, University of Limerick, Castletroy, Limerick V94 T9PX, Ireland.
Mohamed R NoorDepartment of Physics, Bernal Institute and Department of Chemical Sciences, Bernal Institute, University of Limerick, Castletroy, Limerick V94 T9PX, Ireland.
Laura PastorinoDepartment of Informatics, Bioengineering, Robotics and Systems Engineering, University of Genova, Via Opera Pia, 13, 16145 Genova, Italy.
Enrico BagnoliDepartment of Physics, Bernal Institute and Department of Chemical Sciences, Bernal Institute, University of Limerick, Castletroy, Limerick V94 T9PX, Ireland.
Aladin ManiDepartment of Physics, Bernal Institute and Department of Chemical Sciences, Bernal Institute, University of Limerick, Castletroy, Limerick V94 T9PX, Ireland.
Edel DurackDepartment of Physics, Bernal Institute and Department of Chemical Sciences, Bernal Institute, University of Limerick, Castletroy, Limerick V94 T9PX, Ireland.
Alexei AntipovPlasmaChem GmbH, Schwarzschildstr. 10, 12489 Berlin, Germany.
Francesca D'AutiliaNanophysics, Istituto Italiano di Tecnologia, Via Morego, 30, 16163 Genova, Italy.
Paolo BianchiniNanophysics, Istituto Italiano di Tecnologia, Via Morego, 30, 16163 Genova, Italy.
Alberto DiasproNanophysics, Istituto Italiano di Tecnologia, Via Morego, 30, 16163 Genova, Italy.
Tewfik SoulimaneDepartment of Physics, Bernal Institute and Department of Chemical Sciences, Bernal Institute, University of Limerick, Castletroy, Limerick V94 T9PX, Ireland.
Christophe SilienDepartment of Physics, Bernal Institute and Department of Chemical Sciences, Bernal Institute, University of Limerick, Castletroy, Limerick V94 T9PX, Ireland.
Carmelina RuggieroDepartment of Informatics, Bioengineering, Robotics and Systems Engineering, University of Genova, Via Opera Pia, 13, 16145 Genova, Italy.
Syed A M TofailDepartment of Physics, Bernal Institute and Department of Chemical Sciences, Bernal Institute, University of Limerick, Castletroy, Limerick V94 T9PX, Ireland.
University of Limerick · IEItalian Institute of Technology · ITUniversity of Genoa · ITPlasmaChem (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug delivery monitoring and tracking in the human body are two of the biggest challenges in targeted therapy to be addressed by nanomedicine. The ability of imaging drugs and micro-/nanoengineered drug carriers and of visualizing their interactions at the cellular interface in a label-free manner is crucial in providing the ability of tracking their cellular pathways and will help understand their biological impact, allowing thus to improve the therapeutic efficacy. We present a fast, label-free technique to achieve high-resolution imaging at the mid-infrared (MIR) spectrum that provides chemical information. Using our custom-made benchtop infrared microscope using a high-repetition-rate pulsed laser (80 MHz, 40 ps), we were able to acquire images with subwavelength resolution (0.8 × λ) at very high speeds. As a proof-of-concept, we embarked on the investigation of nanoengineered polyelectrolyte capsules (NPCs) containing the anticancer drug, docetaxel. These NPCs were synthesized using a layer-by-layer approach built upon a calcium carbonate (CaCO

Identifiers

PMID30023942
PMCPMC6044925
OpenAlexW2807005135

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.