Evidence map›Paper›PMID 30023844›Full record

ArticleACS omega2018

Novel Low-Toxic Derivative of Celastrol Maintains Protective Effect against Acute Renal Injury.

Xun Hu, Mengdi Jia, Yu Fu, Pei Zhang, Zhirong Zhang, Qing Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

  1. Targeting renal tubular epithelial cellsActa pharmaceutica Sinica. B · 2025
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. [Preparation and Characterization of Clopidogrel Bisulfate Liposomes].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2021
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xun HuKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, Department of Pharmaceutics, West China School of Pharmacy, Sichuan University, No. 17 People's South Road, Chengdu 610041, P. R. China.
Mengdi JiaKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, Department of Pharmaceutics, West China School of Pharmacy, Sichuan University, No. 17 People's South Road, Chengdu 610041, P. R. China.
Yu FuKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, Department of Pharmaceutics, West China School of Pharmacy, Sichuan University, No. 17 People's South Road, Chengdu 610041, P. R. China.
Pei ZhangKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, Department of Pharmaceutics, West China School of Pharmacy, Sichuan University, No. 17 People's South Road, Chengdu 610041, P. R. China.
Zhirong ZhangKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, Department of Pharmaceutics, West China School of Pharmacy, Sichuan University, No. 17 People's South Road, Chengdu 610041, P. R. China.
Qing LinKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, Department of Pharmaceutics, West China School of Pharmacy, Sichuan University, No. 17 People's South Road, Chengdu 610041, P. R. China.
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to novelly design and synthesize an amide derivative as a potential substitute of celastrol (CLT). We constituted the compound celastrol-glucosamine (CLG) by conjugating 1-(2-aminoethoxy)-2-glucosamine to celastrol (CLT) and confirmed its chemical structure by

Identifiers

PMID30023844
PMCPMC6045326
OpenAlexW2792188326

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.