Evidence map›Paper›PMID 30023835›Full record

ArticleACS omega2018

Effect of γ-Aminobutyric Acid-Chitosan Nanoparticles on Glucose Homeostasis in Mice.

Yuangang Liu, Weiji Weng, Shibin Wang, Ruimin Long, Hanwen Li, Huihui Li, Tengteng Li, Mengyi Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. The role of GABA in type 1 diabetes.Frontiers in endocrinology · 2024
    Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yuangang LiuCollege of Chemical Engineering, Institutes of Pharmaceutical Engineering, and College of Materials Science and Engineering, Huaqiao University, Xiamen 361021, China.
Weiji WengCollege of Chemical Engineering, Institutes of Pharmaceutical Engineering, and College of Materials Science and Engineering, Huaqiao University, Xiamen 361021, China.
Shibin WangCollege of Chemical Engineering, Institutes of Pharmaceutical Engineering, and College of Materials Science and Engineering, Huaqiao University, Xiamen 361021, China.
Ruimin LongCollege of Chemical Engineering, Institutes of Pharmaceutical Engineering, and College of Materials Science and Engineering, Huaqiao University, Xiamen 361021, China.
Hanwen LiCollege of Chemical Engineering, Institutes of Pharmaceutical Engineering, and College of Materials Science and Engineering, Huaqiao University, Xiamen 361021, China.
Huihui LiCollege of Chemical Engineering, Institutes of Pharmaceutical Engineering, and College of Materials Science and Engineering, Huaqiao University, Xiamen 361021, China.
Tengteng LiCollege of Chemical Engineering, Institutes of Pharmaceutical Engineering, and College of Materials Science and Engineering, Huaqiao University, Xiamen 361021, China.
Mengyi WuCollege of Chemical Engineering, Institutes of Pharmaceutical Engineering, and College of Materials Science and Engineering, Huaqiao University, Xiamen 361021, China.
Huaqiao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus is the most common endocrine disease worldwide; hyperglycemia is a hallmark of this disease. To alleviate the pain caused by diabetes, developing and utilizing effective diabetic drugs to maintain or recover the function of the residual β-cells is an attractive therapeutic approach. γ-aminobutyric acid (GABA) has been shown to have such effects, but it is easy to have reduced GABA activity under physiological conditions. In the present study, GABA-chitosan nanoparticles (GABA-CS NPs) were prepared, and glucose homeostasis, pancreatic β-cell protection, and anti-inflammatory effects of GABA-CS NPs were investigated in vivo. The results showed that blood glucose levels and IL-1β levels in the GABA-CS NP-administered group were both significantly lower, whereas the PDX1 expression was significantly higher than that of the impaired group (

Identifiers

PMID30023835
PMCPMC6044756
OpenAlexW2790989710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.