Evidence map›Paper›PMID 30023791›Full record

ArticleACS omega2018

Stability of the Na

Brenna A Tucker, Jason S Hudson, Lei Ding, Edwin Lewis, Richard D Sheardy, Eugenia Kharlampieva, David Graves

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Thermodynamic Stability of G-Quadruplexes: Impact of Sequence and Environment.Chembiochem : a European journal of chemical biology · 2021
    Review
  12. Article
  13. Article
  14. Sugar Puckering Drives G-Quadruplex Refolding: Implications for V-Shaped Loops.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Brenna A TuckerDepartment of Chemistry, Department of Biochemistry and Molecular Genetics, and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Jason S HudsonDepartment of Chemistry, Department of Biochemistry and Molecular Genetics, and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Lei DingDepartment of Chemistry, Department of Biochemistry and Molecular Genetics, and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Edwin LewisDepartment of Chemistry, Mississippi State University, Mississippi, Mississippi State 39762, United States.
Richard D SheardyDepartment of Chemistry & Biochemistry, Texas Women's University, Denton, Texas 782042, United States.
Eugenia KharlampievaDepartment of Chemistry, Department of Biochemistry and Molecular Genetics, and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
David GravesDepartment of Chemistry, Department of Biochemistry and Molecular Genetics, and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
University of Alabama at Birmingham · USMississippi State University · USTexas Woman's University · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
NCI NIH HHS P30 CA013148
6 · The paper itself

Abstract

G-quadruplexes are higher order DNA structures that play significant roles in gene transcription and telomeric maintenance. The formation and stability of the G-quadruplex structures are under thermodynamic control and may be of biological significance for regulatory function of cellular processes. Here, we report the structural influence and energetic contributions of the adenine bases in the loop sequences that flank G-repeats in human telomeric DNA sequence. Spectroscopic and calorimetric techniques are used to measure the thermal stability and thermodynamic contributions to the stability of human telomeric G-quadruplexes that have been designed with systematic changes of A to T throughout the telomeric sequence. These studies demonstrate that the thermal stability of the G-quadruplex structure is directly related to the number and position of the adenines that are present in the telomeric sequence. The melting temperature (

Identifiers

PMID30023791
PMCPMC6045420
OpenAlexW2785601200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.