Evidence map›Paper›PMID 30023713›Full record

ArticleACS omega2017

Fluorenyl-Loaded Quatsome Nanostructured Fluorescent Probes.

Xinglei Liu, Antonio Ardizzone, Binglin Sui, Mattia Anzola, Nora Ventosa, Taihong Liu, Jaume Veciana, Kevin D Belfield

Abstract read
In one paragraph

Article in ACS omega, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xinglei LiuDepartment of Chemistry and Environmental Science, College of Science and Liberal Arts, New Jersey Institute of Technology, 323 Martin Luther King, Jr., Blvd., Newark, New Jersey 07102, United States.
Antonio ArdizzoneInstitut de Ciencia de Materials de Barcelona (CSIC)-CIBER-BBN, Campus Universitari de Bellaterra, 08193 Cerdanyola, Spain.
Binglin SuiDepartment of Chemistry and Environmental Science, College of Science and Liberal Arts, New Jersey Institute of Technology, 323 Martin Luther King, Jr., Blvd., Newark, New Jersey 07102, United States.
Mattia AnzolaInstitut de Ciencia de Materials de Barcelona (CSIC)-CIBER-BBN, Campus Universitari de Bellaterra, 08193 Cerdanyola, Spain.
Nora VentosaInstitut de Ciencia de Materials de Barcelona (CSIC)-CIBER-BBN, Campus Universitari de Bellaterra, 08193 Cerdanyola, Spain.
Taihong LiuDepartment of Chemistry and Environmental Science, College of Science and Liberal Arts, New Jersey Institute of Technology, 323 Martin Luther King, Jr., Blvd., Newark, New Jersey 07102, United States.
Jaume VecianaInstitut de Ciencia de Materials de Barcelona (CSIC)-CIBER-BBN, Campus Universitari de Bellaterra, 08193 Cerdanyola, Spain.
Kevin D BelfieldDepartment of Chemistry and Environmental Science, College of Science and Liberal Arts, New Jersey Institute of Technology, 323 Martin Luther King, Jr., Blvd., Newark, New Jersey 07102, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Delivery of hydrophobic materials in biological systems, for example, contrast agents or drugs, is an obdurate challenge, severely restricting the use of materials with otherwise advantageous properties. The synthesis and characterization of a highly stable and water-soluble nanovesicle, referred to as a quatsome (QS, vesicle prepared from cholesterol and amphiphilic quaternary amines), that allowed the nanostructuration of a nonwater soluble fluorene-based probe are reported. Photophysical properties of fluorenyl-quatsome nanovesicles were investigated via ultraviolet-visible absorption and fluorescence spectroscopy in various solvents. Colloidal stability and morphology of the nanostructured fluorescent probes were studied via cryogenic transmission electronic microscopy, revealing a "patchy" quatsome vascular morphology. As an example of the utility of these fluorescent nanoprobes, examination of cellular distribution was evaluated in HCT 116 (an epithelial colorectal carcinoma cell line) and COS-7 (an African green monkey kidney cell line) cell lines, demonstrating the selective localization of

Identifiers

PMID30023713
PMCPMC6044886

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.