Evidence map›Paper›PMID 30023608›Full record

ArticleACS omega2017

Evaluation of Silk Inverse Opals for "Smart" Tissue Culture.

Peter Tseng, Siwei Zhao, Annie Golding, Matthew B Applegate, Alexander N Mitropoulos, David L Kaplan, Fiorenzo G Omenetto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Peter TsengSilklab, Tufts University, 200 Boston Avenue, Suite 4875, Medford, Massachusetts 02155, United States.
Siwei ZhaoDepartment of Biomedical Engineering, Department of Electrical and Computer Engineering, Department of Physics, and Department of Chemical Engineering, Tufts University, Medford, Massachusetts 02155, United States.
Annie GoldingDepartment of Biomedical Engineering, Department of Electrical and Computer Engineering, Department of Physics, and Department of Chemical Engineering, Tufts University, Medford, Massachusetts 02155, United States.
Matthew B ApplegateSilklab, Tufts University, 200 Boston Avenue, Suite 4875, Medford, Massachusetts 02155, United States.
Alexander N MitropoulosDepartment of Biomedical Engineering, Department of Electrical and Computer Engineering, Department of Physics, and Department of Chemical Engineering, Tufts University, Medford, Massachusetts 02155, United States.
David L KaplanSilklab, Tufts University, 200 Boston Avenue, Suite 4875, Medford, Massachusetts 02155, United States.
Fiorenzo G OmenettoSilklab, Tufts University, 200 Boston Avenue, Suite 4875, Medford, Massachusetts 02155, United States.
Tufts University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Visually tracking the subtle aspects of biological systems in real time during tissue culture remains challenging. Herein, we demonstrate the use of bioactive, cytocompatible, and biodegradable inverse opals from silk as a multifunctional substrate to transduce both the optical information and cells during tissue culture. We show that these substrates can visually track substrate degradation in various proteases during tissue digestion and protein deposition during the growth of mesenchymal stem cells. Uniquely, these substrates can be integrated in multiple steps of tissue culture for simple-to-use, visual, and quantitative detectors of bioactivity. These substrates can also be doped, demonstrated here with gold nanoparticles, to allow additional control of cell functions.

Identifiers

PMID30023608
PMCPMC6044746
OpenAlexW2586678311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.