ArticleACS omega2017
Methyl-β-cyclodextrin Inclusion Complex with β-Caryophyllene: Preparation, Characterization, and Improvement of Pharmacological Activities.
Article in ACS omega, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 53 citations in OpenAlex.
- Cyclodextrin-Grafted Polysaccharides as Sustainable Platforms for Biomedical and Environmental Applications.International journal of molecular sciences · 2026Review
- Supramolecular encapsulation of indigo with β-cyclodextrin and Hydroxypropyl-β-cyclodextrin: a sustainable strategy for enhanced solubility, stability, and reducing agent-free dyeing processes.Bioresources and bioprocessing · 2026Article
- Pilot-Scale Continuous Flow Synthesis of Capsaicinoids and Their Formulation with Cyclodextrins.ACS omega · 2026Article
- Advancing Brain Health Naturally: β-Caryophyllene and Xanthohumol as Neuroprotective Agents.Molecules (Basel, Switzerland) · 2025Review
- Significantly improving the solubility and anti-inflammatory activity of fenofibric acid with native and methyl-substituted beta-cyclodextrins via complexation.Scientific reports · 2025Article
- Synthesis of mangiferin derivatives, complexes, and carriers as potential therapeutic candidates for cancer treatment: an update.Frontiers in pharmacology · 2025Review
- Advancements in application of chitosan and cyclodextrins in biomedicine and pharmaceutics: recent progress and future trends.RSC advances · 2024Review
- Effects of Encapsulation of Caesalpinia sappan L. with Cyclodextrins for Bovine Mastitis.AAPS PharmSciTech · 2023Article
- Preclinical Investigation of Transdermal Route for Enhanced Bio-performance of Duloxetine HCl.AAPS PharmSciTech · 2023Article
- The evaluation ofJournal of drug delivery science and technology · 2023Article
- A novel and water-soluble material for coronavirus inactivation from oseltamivir in the cavity of methyl and sulfated-β-cyclodextrins through inclusion complexation.Journal of pharmaceutical and biomedical analysis · 2022Article
- SARS-CoV-2 main protease (3CLJournal of molecular liquids · 2022Article
- Aurisin A Complexed with 2,6-Di-International journal of molecular sciences · 2022Article
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- ContraDRG: Automatic Partial Charge Prediction by Machine Learning.Frontiers in genetics · 2019Article
- Inclusion Complexes of Citronella Oil withPolymers · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
β-Caryophyllene (BCP) is a sesquiterpene that shows high potential in pharmacological applications. However, these have been drastically limited by the respective volatility and poor water solubility. The present study investigates the formation of inclusion complexes between BCP and methyl-β-cyclodextrin (MβCD) and shows that these complexes promote a significant improvement of the anti-inflammatory, gastric protection, and antioxidant activities relative to neat BCP. It is shown that the solubility of BCP is significantly increased through complexation in phase solubility studies. Inclusion complexes with MβCD in solid state were prepared by three different methods, kneading, rotary evaporation, and lyophilization, with the latter confirmed by differential scanning calorimetry, Fourier transformed infrared spectroscopy, scanning electron microscopy,
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.