Evidence map›Paper›PMID 30023579›Full record

ArticleACS omega2017

Target-Guided Synthesis and Antiplasmodial Evaluation of a New Fluorinated 3-Alkylpyridine Marine Alkaloid Analog.

Camila de Souza Barbosa, Daniel Silqueira Martins Guimarães, Alessandra Mirtes Marques Neves Gonçalves, Maria Cristina da Silva Barbosa, Marília Ladeira Alves E Costa, Clébio Soares Nascimento Júnior, Luciana Guimarães, Renato Márcio Ribeiro-Viana, Fabio Vieira Dos Santos, Cristiana Ferreira Alves de Brito and 2 more

Abstract read
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In one paragraph

Article in ACS omega, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Camila de Souza BarbosaNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del-Rei, Campus Centro Oeste, 35501-296 Divinópolis, Minas Gerais, Brazil.
Daniel Silqueira Martins GuimarãesCentro de Pesquisas René Rachou, Fundação Oswaldo Cruz (FIOCRUZ), 30190-002 Belo Horizonte, Minas Gerais, Brazil.
Alessandra Mirtes Marques Neves GonçalvesNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del-Rei, Campus Centro Oeste, 35501-296 Divinópolis, Minas Gerais, Brazil.
Maria Cristina da Silva BarbosaNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del-Rei, Campus Centro Oeste, 35501-296 Divinópolis, Minas Gerais, Brazil.
Marília Ladeira Alves E CostaNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del-Rei, Campus Centro Oeste, 35501-296 Divinópolis, Minas Gerais, Brazil.
Clébio Soares Nascimento JúniorNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del-Rei, Campus Centro Oeste, 35501-296 Divinópolis, Minas Gerais, Brazil.
Luciana GuimarãesNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del-Rei, Campus Centro Oeste, 35501-296 Divinópolis, Minas Gerais, Brazil.
Renato Márcio Ribeiro-VianaNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del-Rei, Campus Centro Oeste, 35501-296 Divinópolis, Minas Gerais, Brazil.
Fabio Vieira Dos SantosNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del-Rei, Campus Centro Oeste, 35501-296 Divinópolis, Minas Gerais, Brazil.
Cristiana Ferreira Alves de BritoCentro de Pesquisas René Rachou, Fundação Oswaldo Cruz (FIOCRUZ), 30190-002 Belo Horizonte, Minas Gerais, Brazil.
Fernando de Pilla VarottiNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del-Rei, Campus Centro Oeste, 35501-296 Divinópolis, Minas Gerais, Brazil.
Gustavo Henrique Ribeiro VianaNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del-Rei, Campus Centro Oeste, 35501-296 Divinópolis, Minas Gerais, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The need to develop new alternatives for antimalarial treatment is urgent. Herein, we report the synthesis and antimalarial evaluation of a small library of synthetic 3-alkylpyridine marine alkaloid (3-APA) analogs. First, the compounds were evaluated in vitro against

Identifiers

PMID30023579
PMCPMC6045394

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.