Evidence map›Paper›PMID 30023566›Full record

ArticleACS omega2017

Green Transfection: Cationic Lipid Nanocarrier System Derivatized from Vegetable Fat, Palmstearin Enhances Nucleic Acid Transfections.

Priya Dharmalingam, Hari Krishna R Rachamalla, Brijesh Lohchania, Bhanuprasad Bandlamudi, Saravanabhavan Thangavel, Mohankumar K Murugesan, Rajkumar Banerjee, Arabinda Chaudhuri, Chandrashekhar Voshavar, Srujan Marepally

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in ACS omega, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Functionalized Graphene Platforms for Anticancer Drug Delivery.International journal of nanomedicine · 2021
    Review
  6. Review
  7. Nanoscale platforms for messenger RNA delivery.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Priya DharmalingamCentre for Stem Cell Research (CSCR), (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore 632002, India.
Hari Krishna R RachamallaCentre for Lipid Research, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Brijesh LohchaniaCentre for Stem Cell Research (CSCR), (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore 632002, India.
Bhanuprasad BandlamudiCentre for Stem Cell Research (CSCR), (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore 632002, India.
Saravanabhavan ThangavelCentre for Stem Cell Research (CSCR), (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore 632002, India.
Mohankumar K MurugesanCentre for Stem Cell Research (CSCR), (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore 632002, India.
Rajkumar BanerjeeCentre for Lipid Research, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Arabinda ChaudhuriCentre for Lipid Research, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Chandrashekhar VoshavarCentre for Lipid Research, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Srujan MarepallyCentre for Stem Cell Research (CSCR), (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore 632002, India.
Christian Medical College, Vellore · INIndian Institute of Chemical Technology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cationic lipid-guided nucleic acid delivery holds great promise in gene therapy and genome-editing applications for treating genetic diseases. However, the major challenge lies in achieving therapeutically relevant efficiencies. Prior findings, including our own, demonstrated that asymmetry in the hydrophobic core of cationic lipids imparted superior transfection efficiencies. To this end, we have developed a lipid nanocarrier system with an asymmetric hydrophobic core (

Identifiers

PMID30023566
PMCPMC6044896
OpenAlexW2770681556

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.