ArticleContemporary clinical trials communications2018
Metabolic and functional changes in transgender individuals following cross-sex hormone treatment: Design and methods of the GEnder Dysphoria Treatment in Sweden (GETS) study.
Article in Contemporary clinical trials communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Cardiometabolic Risk Assessment in Transgender Individuals-Differential Effect of Sex Hormones and Sex Chromosomes.The Journal of clinical endocrinology and metabolism · 2025Article
- A Preclinical Investigation of Estrogenic Bone Protection in a Hypertensive Rat Model Under Gender-Affirming Hormone Therapy.Biology · 2025Article
- Longitudinal changes in regional fat and muscle composition and cardiometabolic biomarkers over 5 years of hormone therapy in transgender individuals.Journal of internal medicine · 2025Article
- Plasma testosterone concentration is correlated with circulating immune cell abundance in transgender young people on gender-affirming hormone treatment.Frontiers in immunology · 2025Article
- Adipokine secretion and lipolysis following gender-affirming treatment in transgender individuals.Journal of endocrinological investigation · 2024Observational
- Transgender and gender diverse adults' reflections on alcohol counseling and recommendations for providers.The American journal of orthopsychiatry · 2023Article
- Thirty Obesity Myths, Misunderstandings, and/or Oversimplifications: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022.Obesity pillars · 2022Article
- Assessment of anterior thigh muscle size and fat infiltration using single-slice CT imaging versus automated MRI analysis in adults.The British journal of radiology · 2022Article
- Rodent Model of Gender-Affirming Hormone Therapies as Specific Tool for Identifying Susceptibility and Vulnerability of Transgender People and Future Applications for Risk Assessment.International journal of environmental research and public health · 2021Review
- Untargeted Metabolomics Analysis Revealed Lipometabolic Disorders in Perirenal Adipose Tissue of Rabbits Subject to a High-Fat Diet.Animals : an open access journal from MDPI · 2021Article
- Effects of gender affirming hormone therapy on body mass index in transgender individuals: A longitudinal cohort study.Journal of clinical & translational endocrinology · 2020Article
- Article
- Sex and the kidneys: current understanding and research opportunities.Nature reviews. Nephrology · 2019Review
- Individualized medicine: Sex, hormones, genetics, and adverse drug reactions.Pharmacology research & perspectives · 2019Review
- Gender-Affirming Hormone Therapy, Vascular Health and Cardiovascular Disease in Transgender Adults.Hypertension (Dallas, Tex. : 1979) · 2019Review
- Effects of resistance training on depression and cardiovascular disease risk in Black men: Protocol for a randomized controlled trial.Mental health and physical activity · 2019Article
- Sex hormones, aging and cardiometabolic syndrome.Biology of sex differences · 2019Review
- Health considerations for transgender women and remaining unknowns: a narrative review.Therapeutic advances in endocrinology and metabolism · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the divergent male and female differentiation depends on key genes, many biological differences seen in men and women are driven by relative differences in estrogen and testosterone levels. Gender dysphoria denotes the distress that gender incongruence with the assigned sex at birth may cause. Gender-affirming treatment includes medical intervention such as inhibition of endogenous sex hormones and subsequent replacement with cross-sex hormones. The aim of this study is to investigate consequences of an altered sex hormone profile on different tissues and metabolic risk factors. By studying subjects undergoing gender-affirming medical intervention with sex hormones, we have the unique opportunity to distinguish between genetic and hormonal effects.
methodsThe study is a single center observational cohort study conducted in Stockholm, Sweden. The subjects are examined at four time points; before initiation of treatment, after endogenous sex hormone inhibition, and three and eleven months following sex hormone treatment. Examinations include blood samples, skeletal muscle-, adipose- and skin tissue biopsies, arteriography, echocardiography, carotid Doppler examination, whole body MRI, CT of muscle and measurements of muscle strength.
resultsThe primary outcome measure is transcriptomic and epigenomic changes in skeletal muscle. Secondary outcome measures include transcriptomic and epigenomic changes associated with metabolism in adipose and skin, muscle strength, fat cell size and ability to release fatty acids from adipose tissue, cardiovascular function, and body composition.
conclusionsThis study will provide novel information on the role of sex hormone treatment in skeletal muscle, adipose and skin, and its relation to cardiovascular and metabolic disease.
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