ArticleJournal of clinical & translational endocrinology2018
Incidence of hypocalcemia and hypercalcemia in hospitalized patients: Is it changing?
Article in Journal of clinical & translational endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Relative bioavailability and pharmacokinetic comparison of calcium glucoheptonate with calcium carbonate.Pharmacology research & perspectives · 2020Trial
- Multifactorial causes of severe persistent hypercalcemia in an immunosuppressed woman with chronic kidney disease.JCEM case reports · 2026Article
- Therapeutic Plasma Exchange in the Elderly: Rare Indications but Good Tolerability.Journal of clinical apheresis · 2026Article
- Article
- Initial Calcium Derangements in Major Trauma and Outcomes.JAMA network open · 2026Article
- Spectrum and prognosis of CAR-T-related endocrine toxicity: glucose/calcium dysregulation, pituitary axis disorders, and overlap with CRS.Frontiers in medicine · 2026Article
- Philippine Clinical Practice Guidelines for Periodic Health Examination: Screening for Renal, Metabolic, Nutritional, and Endocrine Disorders.Acta medica Philippina · 2026Article
- Prognosis and Phenotypes of Advanced Head and Neck Carcinoma Associated With Hypercalcemia.Head & neck · 2025Observational
- A New Machine Learning Approach for Actual Calcium Measurement.Indian journal of clinical biochemistry : IJCB · 2025Article
- Prevalence and Associated Factors of Hypercalcemia of Malignancy Among Advanced Cancer Patients Attending Palliative Care Unit of a Tertiary Care Hospital in Bangladesh.Cancer reports (Hoboken, N.J.) · 2025Article
- Parathyroid hormone-related protein levels and treatment outcomes in hypercalcemia of malignancy: a retrospective cohort study.JBMR plus · 2025Article
- Severe hypocalcemia in the emergency department: a retrospective cohort study of prevalence, etiology, treatment and outcome.Internal and emergency medicine · 2025Article
- Primary Hyperparathyroidism With Undetectable Intact Parathyroid Hormone.Clinical medicine insights. Endocrinology and diabetes · 2024Article
- Severe hypocalcaemia mimicking acute coronary syndrome.BMJ case reports · 2023Article
- Clinical Profile and Outcomes of Patients With Hypercalcemia in an Indian Tertiary Care Center.Cureus · 2023Article
- Intervention for Treating Depression in Parents of Children with Intellectual Disability of Down's Syndrome: A Sample of Nigerian Parents.Journal of rational-emotive and cognitive-behavior therapy : RET · 2022Article
- Hypercalcemia in IgG4-related disease: coincidental or associated? Case based review.Rheumatology international · 2022Review
- Case report: Denosumab-associated acute heart failure in patients with cardiorenal insufficiency.Frontiers in endocrinology · 2022Article
- Low serum calcium is associated with perioperative blood loss and transfusion rate in elderly patients with hip fracture: a retrospective study.BMC musculoskeletal disorders · 2021Article
- Sex differences in electrolyte imbalances caused by SARS-CoV-2: A cross-sectional study.International journal of clinical practice · 2021Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disorders of calcium metabolism are frequently encountered in routine clinical practice. However limited data are available on the epidemiology of hypocalcemia and hypercalcemia in hospitalized patients. Our aim was to evaluate the frequency of hypocalcemia and hypercalcemia in hospitalized patients. This is a retrospective study based on the laboratory results of all hospitalized subjects (n = 12,334) whose calcemia was determined between January 1st, 2011 and December 31st, 2014. Measurements of serum calcium were carried out by a single centralized laboratory. Hypocalcemia was defined as serum calcium levels <8.2 mg/dl and hypercalcemia as serum calcium levels >10.4 mg/dl. Albumin correction was applied to adjust serum calcium values. Overall, hypocalcemia accounted for 27.72% (n = 3420) and hypercalcemia for 4.74% (n = 585) of the 12,334 inpatients. The highest prevalence of hypocalcemia was found in patients over 65 yr. (n = 2097, 61.31%) vs. younger subjects, while the highest prevalence of hypercalcemia was observed in patients aged 0-18 yr. (n = 380, 64.95%). Hypocalcemia was more often encountered in males (n = 1952, 57.07%) while no gender differences were found regarding hypercalcemia. Incidence of hypocalcemia changed over time varying from 35.42% (n = 1061) in 2011 to 21.93% (n = 672) in 2014 (r = -0.98; p = 0.01). Differently, incidence of hypercalcemia did not significantly increase significantly from 3.47% (n = 104) in 2011 to 6.92% (n = 211) in 2014 (r = 0.94; p = 0.052). Despite increased awareness about electrolytes disturbance, physicians should consider calcium levels because of life-threatening consequences associated to hypo- and hypercalcemia. Patient's gender and age could be associated to a different risk of calcium disturbance in hospitalized patients.
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