Evidence map›Paper›PMID 30023256›Full record

ArticleJournal of microscopy and ultrastructure

Evaluation of the safety of conventional lighting replacement by artificial daylight.

Paul F Seke Etet, Mohammed Farahna, Maher A M Khayr, Khalid M Omar, Ömür G Deniz, Hesham N Mustafa, Nadia O Alatta, Abdulmonem Alhayani, Süleyman Kaplan, Lorella Vecchio

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of microscopy and ultrastructure. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Brain communications · 2021
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Paul F Seke EtetDepartment of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, 51452 Buraydah, Saudi Arabia.
Mohammed FarahnaDepartment of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, 51452 Buraydah, Saudi Arabia.
Maher A M KhayrDepartment of Physics, Faculty of Education, Alzaeim Alazhari University, Khartoum North, Sudan.
Khalid M OmarDepartment of Physics, Faculty of Science and Arts, Almethnab, Qassim University, Saudi Arabia.
Ömür G DenizDepartment of Histology and Embryology, Medical Faculty, Ondokuz Mayis University, 55139, Samsun, Turkey.
Hesham N MustafaDepartment of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Nadia O AlattaFaculty of Radiological Sciences and Nuclear Medicine, National Ribat University, Khartoum, Sudan.
Abdulmonem AlhayaniDepartment of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Süleyman KaplanDepartment of Histology and Embryology, Medical Faculty, Ondokuz Mayis University, 55139, Samsun, Turkey.
Lorella VecchioDepartment of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, 51452 Buraydah, Saudi Arabia.
Qassim University · SAKing Abdulaziz University · SANational Ribat University · SDOndokuz Mayıs University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundShort morning exposure to high illuminance visible electromagnetic radiations termed as artificial daylight is beneficial for the mental health of people living in geographical areas with important seasonal changes in daylight illuminance. However, the commercial success of high illuminance light sources has raised the question of the safety of long hour exposure.

methodsWe have investigated the effect of the replacement of natural daylight by artificial daylight in Swiss mice raised under natural lighting conditions. Mice were monitored for neurotoxicity and general health changes. They were submitted to a battery of conventional tests for mood, motor and cognitive functions' assessment on exposure day (ED) 14 and ED20. Following sacrifice on ED21 due to marked signs of neurotoxicity, the expression of markers of inflammation and apoptosis was assessed in the entorhinal cortex and neurons were estimated in the hippocampal formation.

resultsSigns of severe cognitive and motor impairments, mood disorders, and hepatotoxicity were observed in animals exposed to artificial daylight on ED20, unlike on ED14 and unlike groups exposed to natural daylight or conventional lighting. Activated microglia and astrocytes were observed in the entorhinal cortex, as well as dead and dying neurons. Neuronal counts revealed massive neuronal loss in the hippocampal formation.

conclusionsThese results suggest that long hour exposure to high illuminance visible electromagnetic radiations induced severe alterations in brain function and general health in mice partly mediated by damages to the neocortex-entorhinal cortex-hippocampus axis. These findings raise caution over long hour use of high illuminance artificial light.

Indexed as

BehaviorBright visible lightEntorhinal cortexHippocampusMood disorderMouse

Identifiers

PMID30023256
PMCPMC6025781
OpenAlexW2621124714

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.