Evidence map›Paper›PMID 30023171›Full record

SynthesisNeuroImage. Clinical2018

Neural correlates of exercise training in individuals with schizophrenia and in healthy individuals: A systematic review.

E C D van der Stouwe, J T van Busschbach, B de Vries, W Cahn, A Aleman, G H M Pijnenborg

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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  4. Enhancement of aerobic fitness improves social functioning in individuals with schizophrenia.European archives of psychiatry and clinical neuroscience · 2021
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  7. Review
  8. Article
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  12. Physical activity interventions to improve cognition in first-episode psychosis: What we know so far.European psychiatry : the journal of the Association of European Psychiatrists · 2024
    Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

E C D van der StouweDepartment of Neuroscience, BCN Neuroimaging Center, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 2, 9713, AW, Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, University Center of Psychiatry, Rob Giel Onderzoekcentrum, Hanzeplein 1, 9713, GZ, Groningen, The Netherlands. Electronic address: e.c.d.van.der.stouwe@rug.nl.
J T van BusschbachUniversity of Groningen, University Medical Center Groningen, University Center of Psychiatry, Rob Giel Onderzoekcentrum, Hanzeplein 1, 9713, GZ, Groningen, The Netherlands; Department of Movement and Education, Windesheim University of Applied Sciences, Campus 2-6, 8017, CA, Zwolle, The Netherlands. Electronic address: j.t.van.busschbach@umcg.nl.
B de VriesDepartment of Clinical Psychology, University of Groningen, Grote Kruisstraat 2/1, 9712, TS, Groningen, The Netherlands. Electronic address: b.de.vries@rug.nl.
W CahnDepartment of Psychiatry, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht, Heigelberglaan 100, 3584, CX, Utrecht, The Netherlands. Electronic address: w.cahn@umcutrecht.nl.
A AlemanDepartment of Neuroscience, BCN Neuroimaging Center, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 2, 9713, AW, Groningen, The Netherlands. Electronic address: a.aleman@umcg.nl.
G H M PijnenborgDepartment of Neuroscience, BCN Neuroimaging Center, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 2, 9713, AW, Groningen, The Netherlands; Department of Clinical Psychology, University of Groningen, Grote Kruisstraat 2/1, 9712, TS, Groningen, The Netherlands; Department of Psychotic Disorders, GGZ-Drenthe, Dennenweg 9, 9404, LA, Assen, The Netherlands. Electronic address: g.h.m.pijnenborg@umcg.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A body of evidence has revealed positive effects of physical exercise on behavioral, cognitive and physical outcomes in patients with schizophrenia. Notably, the effect of exercise at the neural level may be particularly relevant as well as it is hypothesized that exercise may stimulate the brain in a way that might normalize neural alterations related to the disorder. The aim of the current systematic review was to provide an up to date overview of studies investigating the neural effects of exercise in individuals with a schizophrenia spectrum disorder and healthy individuals. The majority of included studies focused on hippocampal effects, reporting beneficial effects of exercise. In addition, in schizophrenia increased extrastriate body area (EBA) activation and increased white matter fiber integrity in tracts relevant to the disorder were found and in healthy individuals decreased connectivity of the dorsolateral prefrontal cortex (DLPFC) indicating greater cognitive efficiency was reported. Comparing individuals with a schizophrenia spectrum disorder and healthy individuals within a similar age range, most studies found similar effects on hippocampal volume and white matter tracts for both groups, although the effect in schizophrenia spectrum disorders may be attenuated which is in line with previous literature on brain plasticity. The current review indicates a lack of studies investigating neural correlates other than the hippocampus. Although those studies that did focus on other neural correlates revealed promising results, these have not been replicated in other studies and call for replication. Furthermore, future studies should expand their focus, by investigating neural mechanisms underlying positive effects of physical exercise on positive symptoms, negative symptoms and symptoms such as depression, social withdrawal and social cognition.

Indexed as

BrainExerciseHumansMagnetic Resonance ImagingSchizophreniaWhite MatterExerciseHippocampusMagnetic resonance imaging (MRI)NeuroimagingPhysical activitySchizophrenia spectrum disorder

Identifiers

PMID30023171
PMCPMC6050351

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.