ArticleUnited European gastroenterology journal2018
Lifestyle factors and risk for colorectal polyps and cancer at index colonoscopy in a FIT-positive screening population.
Article in United European gastroenterology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Colorectal Polyp Occurrence Associated With the ZMIZ1-AS1 rs704017 Variant and Hypertension Among Taiwan Biobank Participants.Cancer medicine · 2026Article
- Metabolic risk factors link unhealthy lifestyles to the risk of colorectal polyps in China.Preventive medicine reports · 2023Article
- Serum microRNA Levels as a Biomarker for Diagnosing Non-Alcoholic Fatty Liver Disease in Chinese Colorectal Polyp Patients.International journal of molecular sciences · 2023Article
- Age-Specific Differences in the Risk of Colorectal Precursor Lesions Among Patients with Type 2 Diabetes Undergoing Surveillance Colonoscopy.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Factors Associated with Colorectal Polyps in Middle-Aged and Elderly Populations.International journal of environmental research and public health · 2022Article
- Modulation of tumor environment in colorectal cancer - could gut microbiota be a key player?Frontiers in gastroenterology (Lausanne, Switzerland) · 2022Review
- Association between body mass index and colorectal adenomas: Findings from a case-control study in Vietnam.International journal of cancer · 2021Article
- The clinical utility of a comprehensive psychosomatic assessment in the program for colorectal cancer prevention: a cross-sectional study.Scientific reports · 2021Article
- Gut Microbiota Manipulation as a Tool for Colorectal Cancer Management: Recent Advances in Its Use for Therapeutic Purposes.International journal of molecular sciences · 2020Review
- Visceral Adiposity Index is a predictor of incident colorectal cancer: a population-based longitudinal study.BMJ open gastroenterology · 2020Article
- Combining Red Blood Cell Distribution Width (RDW-CV) and CEA Predict Poor Prognosis for Survival Outcomes in Colorectal Cancer.Journal of Cancer · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany countries have adopted the fecal immunochemical test (FIT) as the primary colorectal cancer (CRC) screening tool; however, its accuracy is limited. Epidemiological studies have shown that obesity and type 2 diabetes increase risk for the disease.
objectiveThe objective of this article is to evaluate the association of colorectal polyps and cancer with comorbidities and lifestyle factors in a population that is part of a FIT-based CRC screening program.
methodsBetween 2005 and 2013, we analyzed 3894 FIT + patients who underwent total colonoscopy. The impact of lifestyle factors on polyps and cancer was assessed using individuals with a negative colonoscopy as the control group. A multivariate logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
resultsWe collected data from 3894 FIT + patients. Obesity (OR 1.29; 95% CI 1.05-1.60) and smoking (OR 1.45; 95% CI 1.24-1.71) were significantly associated with high-risk adenomas. Smoking and heavy alcohol drinking were both independently associated with high risk of CRC (OR 1.50; 95% CI 1.10-2.04 and OR 2.29; 95% CI 1.15-4.58) and colon cancer alone (OR 1.43; 95% CI 1.01-2.02 and OR 3.09; 95% CI 1.53-6.23). Positivity to first round of FIT was associated with high-risk adenomas (OR 1.47; CI 95% 1.26-1.71) and CRC (OR 1.74; 95% CI 1.29-2.36). No associations were found for diabetes.
conclusionIn our FIT + population, lifestyle factors are significantly associated with the risk of carrying high-risk adenomas and CRC. In the future, studies could be aimed at finding better screening strategies through the development of clinical algorithms based on lifestyle changes/comorbidities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.