ArticleUnited European gastroenterology journal2018
The distribution of HLA DQ2 and DQ8 haplotypes and their association with health indicators in a general Danish population.
Article in United European gastroenterology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06179121 ("Adding DNA-test for Screening of HLA-DQ2 and DQ8 to Improve the Early Diagnosis of Celiac Disease at the Dutch Preventive Youth Healthcare Centres), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
"Adding DNA-test for Screening of HLA-DQ2 and DQ8 to Improve the Early Diagnosis of Celiac Disease at the Dutch Preventive Youth Healthcare Centres (GLUTEN-GEN)"
Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- The effect of gluten in adolescents and young adults with gastrointestinal symptoms: a blinded randomised cross-over trial.Alimentary pharmacology & therapeutics · 2022Trial
- Frequency of HLA-DQ, susceptibility genotypes for celiac disease, in Brazilian newborns.Molecular genetics & genomic medicine · 2018Trial
- Association between human leukocyte antigen-DQ2/DQ8 positivity and incident atrial fibrillation in patients with heart failure with reduced ejection fraction.Revista da Associacao Medica Brasileira (1992) · 2026Article
- High-resolution analysis of the treated coeliac disease microbiome reveals strain-level variation.Gut microbes · 2025Article
- Article
- HLA-DQ2 and HLA-DQ8 Haplotypes in Heart Failure Patients with Reduced Ejection Fraction.Oman medical journal · 2025Article
- Micronutrient Deficiencies as Early Signs of Celiac Disease: Exemplified by Two Cases.Canadian journal of gastroenterology & hepatology · 2025Article
- What is the incidence of celiac disease in patients with microscopic colitis? Why are these two diseases related?Przeglad gastroenterologiczny · 2024Article
- Unraveling the Immunopathological Landscape of Celiac Disease: A Comprehensive Review.International journal of molecular sciences · 2023Review
- HLA-DQ and alcohol in the pathogenesis of irritable bowel syndrome in college students: a case-control study.Scientific reports · 2023Article
- Type 2 Transglutaminase in Coeliac Disease: A Key Player in Pathogenesis, Diagnosis and Therapy.International journal of molecular sciences · 2022Review
- Severe weight loss in a hypothyroid patient as an acute presentation of autoimmune polyglandular syndrome type II.Hormones (Athens, Greece) · 2022Review
- Up-Regulation of Specific Bioactive Lipids in Celiac Disease.Nutrients · 2021Article
- Evaluation of the Utility of Amino Acid Citrulline as a Surrogate Metabolomic Biomarker for the Diagnosis of Celiac Disease.Nutrition and metabolic insights · 2021Article
- The Gluten Gene: Unlocking the Understanding of Gluten Sensitivity and Intolerance.The application of clinical genetics · 2021Review
- Alterations in One-Carbon Metabolism in Celiac Disease.Nutrients · 2020Article
- Article
- The Role of Early Programming and Early Nutrition on the Development and Progression of Celiac Disease: A Review.Nutrients · 2020Review
- Association of HLA Typing and Alloimmunity With Posttransplantation Membranous Nephropathy: A Multicenter Case Series.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2020Article
- Collagenous Gastritis in Children: Incidence, Disease Course, and Associations With Autoimmunity and Inflammatory Markers.Clinical and translational gastroenterology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman leukocyte antigen (HLA) DQ2 and DQ8 are important risk factors for some autoimmune diseases such as celiac disease (CD), but their possible role in other diseases and health conditions is not fully explored.
objectivesThe objective of this article is to examine the distribution of HLA DQ2 and HLA DQ8 in an adult general population, and their association with health indicators (diseases, symptoms and biomarkers).
methodsIn this cross-sectional, population-based study, 2293 individuals were screened for HLA DQ2 and DQ8; CD-associated alleles (DQA*0201*03*05/DQB*02*0301/0304*0302/0305) and DQB1*02 homozygosity were determined for screen-positive participants. The National Patient Registry provided diagnosis information.
resultsA total of 47.7% (1093/2293) individuals were positive for DQ2 and/or DQ8: 31.2% (716/2293) only DQ2, 11.9% (273/2293) only DQ8, 4.1% (93/2293) both DQ2 and DQ8. Among nine individuals diagnosed with CD, 89.9% (8/9) had DQ2.5
conclusionIn this general Danish population, 47.7% were HLA DQ2/DQ8 positive and thus potentially at risk for CD. All individuals with CD were DQ2/DQ8 positive; the majority DQ2.5. Surprisingly, DQ2/DQ8-positivity was associated with lower IBS prevalence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.