Evidence map›Paper›PMID 30023020›Full record

ArticleNanobiomedicine

Modified Seed Growth of Iron Oxide Nanoparticles in Benzyl Alcohol - Optimization for Heating and Broad Stability in Biomedical Applications.

Stanley E Gilliland, Everett E Carpenter, Michael D Shultz

Abstract read
In one paragraph

Article in Nanobiomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stanley E GillilandResearch and Development, Hunter Holmes McGuire VA Medical Center, Richmond, USA.
Everett E CarpenterDepartment of Chemistry and Nanomaterials Core Characterization Facility, Virginia Commonwealth University, Richmond, USA.
Michael D ShultzResearch and Development, Hunter Holmes McGuire VA Medical Center, Richmond, USA.

Funding

Nanoplatform Delivery of MDA-7 and Brachytherapy for Treatment of Brain TumorsIK2BX001561 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI SHULTZ, MICHAEL D · 2013 to 2017
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BLRD VA IK2 BX001561
6 · The paper itself

Abstract

Iron oxide nanoparticles have received sustained interest for biomedical applications as synthetic approaches are continually developed for control of nanoparticle properties. However, many approaches focus solely on the material, rather than the complete optimization of synthesis and functionalization together to enhance translation into biological systems. Presented herein is a modified seed growth method designed for obtaining optimal nanoparticle properties and ease of surface functionalization for long term stability. With a one or two addition process, iron oxide nanoparticles were produced in crystallite sizes ranging from 5-15 nm using only benzyl alcohol and an iron precursor. In the functionalization process, concentration variations were required for stabilizing different nanoparticle sizes. Radio frequency induction heating experiments of various crystallite and hydrodynamic sizes verified that the heating efficiency greatly increased while approaching the 15 nm crystallite, and suggested an important role of the overall particle size on heating efficiency. Initial

Indexed as

benzyl alcoholbiocompatible materialscancer therapyhyperthermiamagnetic iron oxide nanoparticles

Identifiers

PMID30023020
PMCPMC6029237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.