Evidence map›Paper›PMID 30023016›Full record

ReviewNanobiomedicine

Micro and Nano-Scale Technologies for Cell Mechanics.

Mustafa Unal, Yunus Alapan, Hao Jia, Adrienn G Varga, Keith Angelino, Mahmut Aslan, Ismail Sayin, Chanjuan Han, Yanxia Jiang, Zhehao Zhang and 1 more

Abstract readReview
In one paragraph

Review in Nanobiomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Manipulation of Axonal Outgrowth via Exogenous Low Forces.International journal of molecular sciences · 2020
    Review
  8. Biomedical optics express · 2020
    Article
  9. Review
  10. Hypoxia-enhanced adhesion of red blood cells in microscale flow.Microcirculation (New York, N.Y. : 1994) · 2017
    Article
  11. Article
  12. Review
  13. Article
  14. A toolbox to explore the mechanics of living embryonic tissues.Seminars in cell & developmental biology · 2016
    Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mustafa UnalDepartment of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, USA.
Yunus AlapanDepartment of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, USA.
Hao JiaDepartment of Biology, Case Western Reserve University, Cleveland, USA.
Adrienn G VargaDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, USA.
Keith AngelinoDepartment of Civil Engineering, Case Western Reserve University, Cleveland, USA.
Mahmut AslanDepartment of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, USA.
Ismail SayinCase Biomanufacturing and Microfabrication Laboratory, Case Western Reserve University, Cleveland, USA.
Chanjuan HanDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, USA.
Yanxia JiangDepartment of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, USA.
Zhehao ZhangDepartment of Civil Engineering, Case Western Reserve University, Cleveland, USA.
Umut A GurkanDepartment of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell mechanics is a multidisciplinary field that bridges cell biology, fundamental mechanics, and micro and nanotechnology, which synergize to help us better understand the intricacies and the complex nature of cells in their native environment. With recent advances in nanotechnology, microfabrication methods and micro-electro-mechanical-systems (MEMS), we are now well situated to tap into the complex micro world of cells. The field that brings biology and MEMS together is known as Biological MEMS (BioMEMS). BioMEMS take advantage of systematic design and fabrication methods to create platforms that allow us to study cells like never before. These new technologies have been rapidly advancing the study of cell mechanics. This review article provides a succinct overview of cell mechanics and comprehensively surveys micro and nano-scale technologies that have been specifically developed for and are relevant to the mechanics of cells. Here we focus on micro and nano-scale technologies, and their applications in biology and medicine, including imaging, single cell analysis, cancer cell mechanics, organ-on-a-chip systems, pathogen detection, implantable devices, neuroscience and neurophysiology. We also provide a perspective on the future directions and challenges of technologies that relate to the mechanics of cells.

Indexed as

BiophysicsMechanical ManipulationMicrofabricationMicrofluidicsNanofabricationSingle Cell Analysis

Identifiers

PMID30023016
PMCPMC6029242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.