Evidence map›Paper›PMID 30023006›Full record

ArticleTherapeutic advances in medical oncology2018

Frequency, impact and a preclinical study of novel

Naomi Elster, Sinead Toomey, Yue Fan, Mattia Cremona, Clare Morgan, Karolina Weiner Gorzel, Una Bhreathnach, Malgorzata Milewska, Madeline Murphy, Stephen Madden and 16 more

Open access · goldAbstract read
In one paragraph

Article in Therapeutic advances in medical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 5 institutions in 2 countries.

Naomi ElsterMedical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland.ORCID https://orcid.org/0000-0003-3865-5662
Sinead ToomeyMedical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Yue FanConway Institute, University College Dublin, Ireland.
Mattia CremonaMedical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Clare MorganMedical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Karolina Weiner GorzelConway Institute, University College Dublin, Ireland.
Una BhreathnachConway Institute, University College Dublin, Ireland.
Malgorzata MilewskaMedical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Madeline MurphyConway Institute, University College Dublin, Ireland.
Stephen MaddenData Science Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.
Jarushka NaidooMemorial Sloan-Kettering Cancer Centre, New York, USA.
Joanna FayDepartment of Pathology, Royal College of Surgeons in Ireland, Dublin, Ireland.
Elaine KayDepartment of Pathology, Royal College of Surgeons in Ireland, Dublin, Ireland.
Aoife CarrMedical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Sean KennedyMedical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Simon FurneyDepartment of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Janusz MezynskiBeaumont Hospital, Dublin, Ireland.
Oscar BreathhnachBeaumont Hospital, Dublin, Ireland.
Patrick MorrisBeaumont Hospital, Dublin, Ireland; Department of Medicine, Royal College of surgeons in Ireland, Dublin, Ireland.
Liam GroganBeaumont Hospital, Dublin, Ireland.
Arnold HillBeaumont Hospital, Dublin, Ireland.
Susan Kennedy
John CrownSt Vincent's University Hospital, Dublin, Ireland.
William GallagherConway Institute, University College Dublin, Ireland.
Bryan Hennessy
Alex EustaceMedical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID https://orcid.org/0000-0002-4092-1360
Royal College of Surgeons in Ireland · IEUniversity College Dublin · IEBeaumont Hospital · IEMemorial Sloan Kettering Cancer Center · USSt. Vincent's University Hospital · IE

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundSomatic mutations in the

methodsWe performed Agena MassArray analysis of 227 HER2+ breast cancer samples to identify the type and frequency of

resultsA total of 12 somatic, likely deleterious mutations in the kinase and furin-like domains of the

conclusions

Indexed as

breast cancerHER2+ BCPI3KPI3K inhibitionsomatic mutationstrastuzumab resistance

Identifiers

PMID30023006
PMCPMC6047239
OpenAlexW2882979755

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.