Evidence map›Paper›PMID 30022934›Full record

ArticleCase reports in dermatology

Bullous Pemphigoid as an Adverse Reaction to Pembrolizumab: Two Case Reports.

Kenneth Thomsen, Jon Diernaes, Trine Heide Øllegaard, Eva Spaun, Christian Vestergaard

Abstract readCase Reports
In one paragraph

Article in Case reports in dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Bullous pemphigoid.Anais brasileiros de dermatologia
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kenneth ThomsenDepartment of Dermatology, Aarhus University Hospital, Aarhus, Denmark.
Jon DiernaesDepartment of Dermatology, Aarhus University Hospital, Aarhus, Denmark.
Trine Heide ØllegaardDepartment of Oncology, Aarhus University Hospital, Aarhus, Denmark.
Eva SpaunDepartment of Pathology, Aarhus University Hospital, Aarhus, Denmark.
Christian VestergaardDepartment of Dermatology, Aarhus University Hospital, Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Checkpoint inhibitors are novel and promising treatment options for different types of cancer. Programmed cell death 1 (PD-1) inhibitors, such as pembrolizumab, have been shown to significantly raise the survival rates of disseminated malignant melanoma (MM). Autoimmune adverse reactions are very common in checkpoint inhibitors. We present 2 cases of bullous pemphigoid, as adverse reactions to pembrolizumab-treated MM.

Indexed as

Adverse drug reactionAutoimmune bullous diseasesAutoimmune diseasesBullous pemphigoidBullous skin diseaseCheckpoint inhibitorsMalignant melanomaPembrolizumabProgrammed cell death 1

Identifiers

PMID30022934
PMCPMC6047493

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.