Evidence map›Paper›PMID 30022836›Full record

ArticleOncoTargets and therapy2018

Overexpression of DJ-1 correlates with aggressive clinicopathological characteristics and poor prognosis in malignant tumors: a meta-analysis.

Qingting Wang, Fangwei Li, Wenhua Shi, Qianqian Zhang, Jian Wang, Xin Yan, Limin Chai, Manxiang Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OncoTargets and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Qingting WangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China, manxiangli@hotmail.com.
Fangwei LiDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China, manxiangli@hotmail.com.
Wenhua ShiDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China, manxiangli@hotmail.com.
Qianqian ZhangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China, manxiangli@hotmail.com.
Jian WangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China, manxiangli@hotmail.com.
Xin YanDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China, manxiangli@hotmail.com.
Limin ChaiDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China, manxiangli@hotmail.com.
Manxiang LiDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China, manxiangli@hotmail.com.
First Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA number of studies have investigated the role of DJ-1 in the development and progression of malignant tumors. This meta-analysis aims to systematically estimate the rela-tionship between the expression level of DJ-1 and the malignant biological behaviors of tumors and to assess the clinical significances of DJ-1 in the prognosis and diagnosis of cancer. MATERIALS AND

methodsWe searched PubMed, Web of Science, China National Knowledge Infrastructure and Wanfang databases from inception to December 1, 2017. Pooled odds ratio (OR) and hazard ratio (HR) with their 95% confidence interval and the diagnostic value of DJ-1 were calculated.

resultsFourteen eligible studies with a total of 1,947 subjects were enrolled in our meta-analysis. The results showed that DJ-1 was overexpressed in cancer patients compared with noncancer patients (OR = 30.72), and elevated expression of DJ-1 was demonstrated to be closely associated with high tumor-node-metastasis stage (OR = 5.52), poor differentiated degree (OR = 2.46), positive lymph node metastasis (OR = 4.12) and worse overall survival (HR = 2.23). In addition, the combined sensitivity and specificity for DJ-1 to discern malignant tumors were 0.73 and 0.93, respectively. The diagnostic OR was 34.87, and the area under the summary receiver operating characteristic curve was 0.88.

conclusionThis meta-analysis demonstrated that DJ-1 was an important biomarker in tumor assessment and prognosis prediction.

Indexed as

diagnosisDJ-1malignant tumormeta-analysisprognosis

Identifiers

PMID30022836
PMCPMC6042497
OpenAlexW2854954396

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.